[PDF][PDF] Lipopolysaccharide-induced necroptosis of brain microvascular endothelial cells can be prevented by inhibition of endothelin receptors

Y Abdul, R Ward, G Dong, A Ergul - Physiological research, 2018 - biomed.cas.cz
… toll like receptor 4 (TLR4), which also happens to stimulate ET-1 production in … cells. To
establish the effect of ET-1 on PCD and survival of human brain microvascular endothelial cells (…

[HTML][HTML] Endothelin-1 mediates brain microvascular dysfunction leading to long-term cognitive impairment in a model of experimental cerebral malaria

BD Freeman, YC Martins, OB Akide-Ndunge… - PLoS …, 2016 - journals.plos.org
… increase in brain microvascular endothelial cell activation, … As BQ123 does not cross the
BBB [57], the partial protection of … , tissue inhibitors of MMPs and TACE in experimental cerebral

Brain vasculature and cognition: Renin-angiotensin system, endothelin, and beyond

AY Fouda, SC Fagan, A Ergul - Arteriosclerosis, thrombosis, and …, 2019 - Am Heart Assoc
… In brain microvascular endothelial cells, inhibition of the ET B … properties of brain microvascular
endothelial cells under … In addition, AT1 blockade protects against diabetes mellitus–…

Endothelin receptor antagonists alleviate blood-brain barrier disruption and cerebral edema in a mouse model of traumatic brain injury: A comparison between …

S Michinaga, A Inoue, H Yamamoto, R Ryu, A Inoue… - …, 2020 - Elsevier
brain microvessel endothelial cells, ET-1 (100 nM) increased prepro--ET-1 mRNA, which was
inhibited … In addition to indicating the effectiveness of ET receptor antagonism in protecting

Targeting endothelin in Alzheimer's disease: a promising therapeutic approach

S Sharma, T Behl, A Kumar, A Sehgal… - BioMed Research …, 2021 - Wiley Online Library
… the levels of endothelin in the brain from endothelial cells. … to protect the brain from reduced
blood flow toward the brain. … antagonized by using the ECE1 inhibitor phosphoramidon. The …

Microvasospasms after experimental subarachnoid hemorrhage do not depend on endothelin a receptors

H Liu, A Dienel, K Schöller, SM Schwarzmaier… - Stroke, 2018 - Am Heart Assoc
… of ET A receptor inhibition on early microcirculatory … A receptors in early post-SAH changes
in the cerebral microcirculation. We found that pharmacological inhibition of ET A receptors

Porphyromonas gingivalis infection upregulates the endothelin (ET) system in brain microvascular endothelial cells

E Karakaya, Y Abdul, N Chowdhury… - Canadian journal of …, 2022 - cdnsciencepub.com
… The inhibition of ETA and ETB receptors with BQ123 or BQ788, respectively, did not lead to
… form the BBB that protects the brain, direct infection and damage to these cells may be one …

[PDF][PDF] Endothelin and diabetic complications: a brain-centric view

W Li, Y Abdul, R Ward, A Ergul - Physiological research, 2018 - biomed.cas.cz
… properties of brain microvascular endothelial cells isolated … impairs endothelial cell-mediated
vasodilatation of cerebral … WG: Inhibition of endothelin-1 receptors improves impaired …

[HTML][HTML] C3a receptor inhibition protects brain endothelial cells against oxygen-glucose deprivation/reperfusion

S Ahmad, A Kindelin, SA Khan, M Ahmed… - Experimental …, 2019 - ncbi.nlm.nih.gov
receptor is involved in brain endothelial activation [30], and the brain microvascular endothelial
cells … study, we utilized a model of murine brain microvascular endothelial cells (b.End.3) …

[HTML][HTML] Delta Opioid Peptide Targets Brain Microvascular Endothelial Cells Reducing Apoptosis to Relieve Hypoxia-Ischemic/Reperfusion Injury

R Zhang, M Chen, Z Deng, L Kong, B Shen, L Zhang - Pharmaceutics, 2022 - mdpi.com
… can induce autophagy and inhibit apoptosis in astrocytes [12]. … of endothelin release from
cultured porcine aortic endothelial … function could be significantly inhibited by the antagonist of …