Discovering new mTOR inhibitors for cancer treatment through virtual screening methods and in vitro assays

L Wang, L Chen, M Yu, LH Xu, B Cheng, YS Lin… - Scientific reports, 2016 - nature.com
… of cell growth inhibition by compound 17, … inhibitors identified in the present study provided
valuable alternatives for further development into therapeutic candidates for cancer treatment. …

Akt inhibitors in cancer treatment: The long journey from drug discovery to clinical use

GM Nitulescu, D Margina… - International …, 2016 - spandidos-publications.com
… An isosteric scaffold of adenosine, the 4-aminopyrido[2,3-d]pyrimidine derivative API-1 was
discovered to inhibit Akt by screening the DTP/NCI compound library in a cell-based assay. …

Computational Evaluation of Bioactive Compounds from Colocasia affinis Schott as a Novel EGFR Inhibitor for Cancer Treatment

TA Balogun, N Ipinloju, OT Abdullateef… - Cancer …, 2021 - journals.sagepub.com
… EGFR inhibitors and FDA-approved drugs for cancer treatment. EGFR inhibitors function
either … The theoretical methods employed to compare the chemical and biological activities of …

Melatonin: a new inhibitor agent for cervical cancer treatment

R Shafabakhsh, RJ Reiter, H Mirzaei… - Journal of cellular …, 2019 - Wiley Online Library
… Current treatment options often have severe side effects and … Melatonin is an indolamine
compound secreted from the … improve the therapeutic impacts of different anticancer drugs. Thus…

[PDF][PDF] Invention of (Gluta. Sulfazane-Cefixime) Compounds as Inhibitors of Cancerous Tumors

IKA Alsabri, HK Abdullabass… - … Disease Research, 2020 - researchgate.net
… of treatment such as new drugs, new methods of … inhibition of cancer cells (Throat Cancer)
for all innovative pharmaceutical compounds that prepared in this research, and compound{2} …

[HTML][HTML] Curcumin as tyrosine kinase inhibitor in cancer treatment

A Golonko, H Lewandowska, R Świsłocka… - European Journal of …, 2019 - Elsevier
… Many years of research allowed a thorough analysis of the mechanism of tyrosine … new
therapeutic methods using synthetic chemical compounds with the properties of kinase inhibitors. …

Dual inhibitors as a new challenge for cancer multidrug resistance treatment

T Stanković, J Dinić, A Podolski-Renić… - Current Medicinal …, 2019 - ingentaconnect.com
… designed to target microtubules and other targets within cancer cell, compounds that target
inhibitor approved for cancer treatment, specifically advanced non–small cell lung cancer (…

The search for potent, small‐molecule HDACIs in cancer treatment: a decade after vorinostat

C Zagni, G Floresta, G Monciino… - Medicinal research …, 2017 - Wiley Online Library
… These compounds demonstrated significant HDAC inhibitory activities and antiproliferative
… was 15l that resulted equipotent to SB939 in cancer cell growth and also in HDAC inhibition

New approaches and procedures for cancer treatment: Current perspectives

DT Debela, SGY Muzazu, KD Heraro… - SAGE open …, 2021 - journals.sagepub.com
… and therapeutic options. Targeted therapy possessed breakthrough potential inhibiting the
… do work in different ways from standard chemotherapy drugs treatment like attacking cancer

Strategies and approaches of targeting STAT3 for cancer treatment

SL Furtek, DS Backos, CJ Matheson… - ACS chemical …, 2016 - ACS Publications
… STAT3 inhibitors organized by the approach used to inhibit … A number of small molecule
compounds directly inhibit the … However, methods surrounding dosing with compounds remain …