Signaling pathways of the insulin-like growth factor binding proteins

RC Baxter - Endocrine Reviews, 2023 - academic.oup.com
… Given the rapidly expanding knowledge of IGFBP actions … ambient IGFs in the cell culture
medium, might cause IGF1R … intracellular pathways distinct from IGF1R signal transduction, …

Insulin-like growth factor pathway and the thyroid

TJ Smith - Frontiers in endocrinology, 2021 - frontiersin.org
… belonging to the insulin and insulin-like growth factor-I (IGF-I) … in cultured thyroid epithelial
cells has been shown to activate … of the multiple downstream signal transduction pathways

[HTML][HTML] Insulin-like growth factors: Ligands, binding proteins, and receptors

D LeRoith, JMP Holly, BE Forbes - Molecular metabolism, 2021 - Elsevier
… action of signal transducer and activator of transcription 5b (… intact IGFBP-3 almost entirely
due to a faster off rate [102]. This … of the ECM in fibroblast cultures, which reduces its affinity for …

… -like growth factors are essential to prevent anoikis in oestrogen-responsive breast cancer cells: importance of the type I IGF receptor and PI3-kinase/Akt pathway

BC Luey, FEB May - Molecular cancer, 2016 - Springer
Multiple signal transduction pathways can activate anoikis … MCF-7, ZR-75 and EFM-19 cells
were cultured for two days in … pathway in oestrogen-responsive breast cancer as the rapid

How ligand binds to the type 1 insulin-like growth factor receptor

Y Xu, GKW Kong, JG Menting, MB Margetts… - Nature …, 2018 - nature.com
… form and in complex with insulin-like growth factor I, the latter … passaging several times in
T150 tissue culture flasks at 37 C/… , it is assumed that ligand dissociates instantly which leads to …

The insulin-like growth factor signalling pathway in cardiac development and regeneration

S Díaz del Moral, M Benaouicha… - International journal of …, 2021 - mdpi.com
… The heart undergoes rapid growth in order to meet the … is a highly conserved system
regulating multiple cellular … with HASF inhibits apoptosis in culture and direct injection of HASF …

Combinatorial effects of epidermal growth factor, fibroblast growth factor 2 and insulin-like growth factor 1 on trophoblast cell proliferation and embryogenesis in cattle

M Xie, SR McCoski, SE Johnson… - Reproduction, Fertility …, 2017 - CSIRO Publishing
… the culture medium with individual or multiple factors during … to examine the involvement of
these signalling pathways in EGF-, … 2011c), in the present study FGF2 did not produce a rapid, …

Autocrine secretion of insulin-like growth factor-I mediates growth hormone-stimulated DNA synthesis and proliferation in primary cultures of adult rat hepatocytes

K Kurihara, H Moteki, M Kimura, M Ogihara - European Journal of …, 2021 - Elsevier
… IGF-I levels in the culture medium increased rapidly versus … The relationship between these
two signaling pathways is not … mediated intracellular signal transduction pathways that play …

Insulin-like growth factor 1-receptor signaling stimulates GRP78 expression through the PI3K/AKT/mTOR/ATF4 axis

DP Ha, AS Lee - Cellular signalling, 2020 - Elsevier
… where there is rapid cell growth and proliferation resulting in … (PI3K) pathways which are
the two major pro-survival and pro-… The cells were cultured under normal non-stressed culture

Effects of obesity on insulin: insulin-like growth factor 1 hybrid receptor expression and Akt phosphorylation in conduit and resistance arteries

RS Mughal, K Bridge, I Buza, R Slaaby… - Diabetes and …, 2019 - journals.sagepub.com
… After 15 min stimulation, mice were euthanised and the aorta rapidly … We did not observe
any discernible difference in the two … We cultured HUVECs in conditions aiming to recapitulate …