The objective of this comprehensive review is to summarize and discuss the available evidence
of how adipose tissue inflammation affects insulin sensitivity and glucose tolerance. Low-…

… Finally, a standard oral glucose tolerance test (OGTT) was … in skeletal muscle despite reducing
adipose tissue GLUT4 (28). … adipose tissue has a reduced insulin-mediated suppression …

… rate is increased in impaired glucose tolerance (IGT) (2) and in … insulin-mediated suppression
of NEFA release by lipolysis of … Altered skeletal muscle fatty acid handling in subjects with …

… a crucial role in insulin-mediated glucose disposal. Myokines have … obese mice reversed
their glucose intolerance and restored … via skeletal muscle glucose uptake, white adipose tissue …

… storage in liver and skeletal muscle, and insulin resistance 57 … of adipose DNL to fatty acids
stored in human adipose tissue … full ATGL activation in stimulated lipolytic states. Mutations in …

… , skeletal muscle, and adipose tissue by suppressing hepatic … increases insulin-mediated
glucose uptake in skeletal muscle, … lipid accumulation and improves glucose tolerance [42, 43]. …

… insulin resistance may cause hepatic and skeletal muscle … measuring the insulin-mediated
suppression of lipolysis. Until … impaired fasting glucose and impaired glucose tolerance (17) …

… in adipose tissue has been shown to be less suppressed in … glucose tolerance (IGT)
compared with impaired fasting … accounts for approximately 80% of insulin-mediated glucose …

… as white adipose tissue (WAT), liver, and skeletal muscle), … ); a required event for
insulin-mediated phosphorylation of Rab-… contribute to whole-body glucose intolerance seen with …

… of glucose uptake in skeletal muscle and adipose tissue, … elevation attenuates the
insulin-mediated suppression of EGP … energy expenditure and improved glucose tolerance (403). …