… emphasis on biomarker discovery and validation to help with … to neoadjuvant chemotherapy
in breast cancer patients [24]. … MS-based protein biomarkers are shown in Table 1 below. …

… Such studies, focused on cancer biomarkers discovery or … biomarkers of breast cancer
metastasis. By the use of iTRAQ-based quantitative tissue proteomics, the authors have shown …

… lipidomics and their application to cancer biomarker discovery. … /ionization mass spectrometry
from a HER2 positive breast cancer (shown in red) and the adjacent normal tissue (shown …

… approaches for target identification and validation, as well as … in a mouse model of visceral
leishmaniasis 64,65 . … inhibitors in living cells and demonstrated selective targeting of BRPF1 (…

… ovarian cancer from a genetically engineered mouse model of … This manuscript
demonstrates the importance of rigorous … biomarkers for early detection: validation of biomarker …

… researchers have resorted to animal models. Nevertheless, the … and chemokine levels, which
displayed no significant inter-… and proteomics analysis has confirmed and extended these …

… Now, bioinformatics pipelines allow researchers to combine … of cancer protein biomarkers
have perhaps best demonstrated the … Validation of biomarker candidates through large-scale …

… Despite this, a top-down approach was shown to provide … -derived xenograft models of
different breast tumor subtypes [Citation5]. … in proteomic cancer biomarker discovery and discuss …

… discovery, verification, and validation phases, as shown in … [89] identified 36 protein biomarkers
of breast cancers, which … cell lines and/or animal models, respectively. For example, Hou …

… exosomal proteins must be demonstrated. Immunoblotting is … identification and validation of
novel protein biomarkers and … patients diagnosed with breast cancer compared with healthy …