… should be integrated into biopredictive dissolution testing (low … poor aqueous solubility
and high permeability, these dynamic … The obtained underlying cumulative dissolution profile …

… planning of incorporating IVIVCs in the drug development. … While the IVIVC development
strategy employed in this study … and highly permeable drug in the upper part of the intestine (…

… the drug was studied in different pH media and permeability … drug in humans by testing the
dissolution profiles of the drug … of the methods which incorporate a deconvolution step can be …

… pH modifiers were integrated into the drug dissolution/absorption … and IVIVCs were predicted
from the dissolution–permeation–… on the dissolution profiles and the permeation dynamics …

… integrated dissolution–absorption models, the dissolution/… dissolved drugs and cause less
disturbance in drug permeation. … very difficult to establish IVIVC for drugs especially exhibiting …

… with design of experiment (DoE) that integrates the DoE into … vitro dissolution and in vivo
drug concentrations, IVIVC allows … IVIVC methods has been limited to highly permeable drugs, …

… can be deconvoluted from the GI transit, drug permeation, … that have dissolution profiles at
the upper and lower dissolution … the potential to incorporate the mechanisms of dissolution and …

… of IVIVC model is to justify the in vitro dissolution profiles as a … 2 where permeability is faster
than the dissolution rate and … the permeability, increasing of the dissolution and permeability …

… utilized to establish and evaluating IVIVC models, as well as … , of which dissolution,
permeability, and transporters can all … , and IVIVC feasibility followed by incorporating an IVIVC …

… validation, the virtual dissolution profiles were integrated into … and pharmaceutical scientists
to use mechanistic IVIVC’s for … systems such as dissolution/permeation (eg PermeaLoop™), …