… beta-2-microglobulin and this interaction is essential … HFE hemochromatosis. Pathogenic
variants of TFR2 gene, which encodes the transferrin receptor 2, cause this type of hereditary …

… On the HuH7 hepatoma cell surface, this Tfr2α/HFE interaction occurs within a multiprotein
complex, that also includes mHjv [27]. It remains to be demonstrated if this complex activates …

… Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests
a molecular … Interaction of the hereditary hemochromatosis protein HFE with transferrin …

… TfR2 forms a complex with hemochromatosis protein, HFE, and … systemic iron overload,
hemochromatosis, through down-… Thus, TfR1 can interact with two iron-carrier proteins with …

… Our results highlight the differences in Tf interactions with the two TfRs. … A better molecular
understanding of the TfR2–HFE–Tf interaction(s) and their direct impact on modulating …

… that gene expression of HFE, transferrin receptor 1 (TfRC) and transferrin receptor 2 (TfR2)
on … loaded transferrin for the binding to the transferrin receptor, but it does not just interact with …

… HFE. Studies directed instead to examining the functional consequences of this interaction
on HFE … by which the interaction of HFE with TFR1 prevents HFE from otherwise exerting an …

… binding of the transferrin protein (TF) with the Transferrin Receptor 1 (TFR1) protein (responsible …
The TF-TFR1 binding displaces the HFE protein that then is free to interact with TFR2 to …

… ) complex and phosphorylates SMAD proteins. The HFE protein/transferrin receptor 2 (TFR2) …
HFE protein can interact with TFR1 and TFR2 [35, 63], and it is probably involved in iron …

… associated to transferrin, the protein that can link up to two iron … of transferrin iron is mediated
by the transferrin receptor 1 (… interaction between TFR1 and HFE proteins when transferrin …