… and VEGFR-3) and two co-receptors (Neuropilin-1 and -2). … generated, displaying inhibitory
activity in vitro [22]. We now … of cell surface VEGFR-1 and VEGFR-2, or intracellular VEGF-B …

… affinity for sFlt-1 in the absence of heparin or neuropilin 1. … VEGF isoform VEGF 95 only
displays reduced interaction with … We introduce the first in vivo applicable apheresis system for …

… and co-receptors: neuropilin-1 and neuropilin-2 leading to the … -family binding interactions
via computational modeling and … Indeed, in vitro evolution is widely used to engineer proteins …

… This work sheds light on how in vitro results of anti-VEGF … immune–cancer interactions
and interpatient heterogeneity. … that exploit mechanistic computational modeling, based on …

… and its receptors have been intensively investigated with computational modeling. … in an
in vitro experimental setting. The patient-to-patient VEGFR1 and neuropilin variability has been …

… receptors that include VEGF receptor VEGFR-1, VEGFR-2, and VEGFR-3 (S… VEGF with
VEGFR-2, we hypothesized that the Nrp-2-VEGF-VEGFR-2 complex induced angiogenesis in vivo…

… In vivo and in vitro VEGF-A causes VEGFR-1 activation and … coreceptors like neuropilins
(NRPs) nor heparan sulfate (HS). … , VEGFR-1 has a higher affinity to VEGF-A than VEGFR-2, …

… -4) and neuropilins (NRPs) acting as VEGF co-receptors [119]. … VEGFR-1 embodies a tyrosine
kinase with decreased activity due to its function as decoy receptor antagonizing VEGFR-2 …

… Since it is not known how or if TSP1 interacts with the … both the experimental study and
computational models, we set the … during full model training using in vitro cell culture datasets. …

… have a direct effect on skeletal muscle, although the mechanism of its … Interactions of VEGF
Isoforms with VEGFR-1, VEGFR-2, and Neuropilin in Vivo: A Computational Model of Human …