… Thus, IFN-I can be protective during influenza virus infection … of immune suppressive
cytokines to quell detrimental … link between IFN-I signaling, immune activation, negative immune …

… In the context of virus infection, however, we hypothesize that type I IFN acts to optimize the
antiviral … beneficial innate immune cell function, while limiting detrimental and pathological …

… by virus-infected cells and interfere with virus replication in … also with harmful effects of type
I IFNs during infection with F. … physiology of type IFNs in the course of bacterial infections. The …

… They also modulate innate and adaptive immune responses. … “interfere” with the ability of a
virus to successfully replicate ( … They play an adverse role in certain bacterial infections, while …

… , IFN responses need to be tightly regulated to achieve protective immunity against microbial
infection while avoiding harmful … in 1957, as a strong interference of life cycle of influenza …

… IFN-λ, in the setting of viral infections (19) as well as other forms of acute inflammation (20–22).
IFN-λ reportedly also interferes … pathway, IFN-λ also down-modulates tissue-damaging, …

… Type I IFN appears to be detrimental through at least three separate… role of IFNs type I and
II, and the recently discovered type III in Mycobacterium tuberculosis (M. tuberculosis) infection …

… difference may provide a clinical advantage of IFN-α for the treatment of chronic HCV infection,
since type III IFNs cause less adverse hematopoietic effects than IFN-α. 55 Oh MD, Park …

… nets will offer additional tools to manage beneficial and detrimental Type-I-IFN immune …
The discovery of IFNs evolved from studies of viral interference beginning in 1950. Since then, …

… During chronic infection and cancer, a new homeostasis is reached such that the negative
effects of IFN-Is … IFN-Is interfere with angiogenesis in three ways: They act directly on vascular …