Immunodeficiencies at the interface of innate and adaptive immunity
… for IL-12 production and for protective immunity against … of IFN-γ because of a lack of stimulation
through the IL-12R. This … The patients with AR complete STAT-1 deficiency had multiple, …
through the IL-12R. This … The patients with AR complete STAT-1 deficiency had multiple, …
Development of functional immune readouts for the confirmation of Mendelian Susceptibility to Mycobacterial Disease and related Primary Immunodeficiencies
A Van Coller - 2019 - scholar.sun.ac.za
… of the IL-12-IFN-γ pathway was successful in identifying immune deficits … to the
Interleukin-12-Interferongamma (IL-12-IFN-γ) pathway, … Signal transduction through IL-12R firstly …
Interleukin-12-Interferongamma (IL-12-IFN-γ) pathway, … Signal transduction through IL-12R firstly …
[HTML][HTML] STAT1 and its crucial role in the control of viral infections
… the CC/DB domain interface or the ND dimer interface block … that STAT-1 increases the levels
of both IL-12 and TNF-α in … this differentiation, IL-12 binds to the IL-12 receptor (IL-12R) and …
of both IL-12 and TNF-α in … this differentiation, IL-12 binds to the IL-12 receptor (IL-12R) and …
Persistent nodal histoplasmosis in nuclear factor kappa B essential modulator deficiency: report of a case and review of infection in primary immunodeficiencies
JP Lovell, L Foruraghi, AF Freeman, G Uzel… - … Clinical Immunology, 2016 - jacionline.org
… , resulting in the production and release of IL-12, which binds to IL-12R on T H 1 and natural
… IL-12/IFN-γ/STAT-1 pathway indicates that the host's ability to produce and respond to IFN-γ …
… IL-12/IFN-γ/STAT-1 pathway indicates that the host's ability to produce and respond to IFN-γ …
[HTML][HTML] Regulation of immunity during visceral Leishmania infection
V Rodrigues, A Cordeiro-da-Silva, M Laforge… - Parasites & vectors, 2016 - Springer
… VL and Acquired Immunodeficiency Syndrome (AIDS), … -bet) and upregulation of IL-12 receptor
(IL-12R) to prime for Th1 … cytokine IFN-γ that through autocrine signaling activates STAT-1 …
(IL-12R) to prime for Th1 … cytokine IFN-γ that through autocrine signaling activates STAT-1 …
Next-generation cytokines for cancer immunotherapy
D Xue, E Hsu, YX Fu, H Peng - Antibody therapeutics, 2021 - academic.oup.com
… [24] PEG conjugated to IFN-α at IFN/IFNR-binding interface … IL-12 binds to the IL-12 receptor
(IL-12R), which is expressed … T cell lymphoma, acquired immunodeficiency syndrome (AIDS)…
(IL-12R), which is expressed … T cell lymphoma, acquired immunodeficiency syndrome (AIDS)…
Disseminated multidrug-resistant tuberculosis and SARS-CoV-2 co-infection in a child with IL-12Rβ1 deficiency
D San-Juan, MP Melgoza, OZ Martínez… - indian journal of …, 2023 - Elsevier
… expression of IL-12R and Interferon gamma receptor 1 (IFN-… evolution of a child with complete
IL-12 Rβ1 deficiency. CNS TB is … or any other cause of immunodeficiency such as MSMD. …
IL-12 Rβ1 deficiency. CNS TB is … or any other cause of immunodeficiency such as MSMD. …
[HTML][HTML] Cytokine receptors—regulators of antimycobacterial immune response
M Druszczyńska, M Godkowicz, J Kulesza… - International Journal of …, 2022 - mdpi.com
… of IL-12 and IFN-β by DC. At the early stage of infection, … receptor (IL-12R) complex, which
is composed of two chains: IL-… either of the two IFN-γR chains or STAT-1 is associated with the …
is composed of two chains: IL-… either of the two IFN-γR chains or STAT-1 is associated with the …
Patients with idiopathic pulmonary nontuberculous mycobacterial disease have normal Th1/Th2 cytokine responses but diminished Th17 cytokine and enhanced …
UI Wu, KN Olivier, DB Kuhns, DL Fink… - … Infectious Diseases, 2019 - academic.oup.com
… a comprehensive study to examine not only the IL-12/IFN-γ axis, but also Th17/Treg cytokine
levels in patients with idiopathic PNTM disease through comparisons with CF and PCD …
levels in patients with idiopathic PNTM disease through comparisons with CF and PCD …
[HTML][HTML] Frequency of Mycobacterium bovis and mycobacteria in primary immunodeficiencies
… infections in primary immunodeficiency diseases. … of the interleukin 12-23/interferon gamma
(IL-12/23-IFN-γ) pathway (1, 2)… for severe combined immune deficiency, IL-12/IFN-γ receptor …
(IL-12/23-IFN-γ) pathway (1, 2)… for severe combined immune deficiency, IL-12/IFN-γ receptor …