Interferon-α may help prevent molecular relapse of chronic myeloid leukemia after the discontinuation of tyrosine kinase inhibitors

K Jun, Q Ya-Zhen, Z Xiao-Su… - Therapeutic …, 2021 - journals.sagepub.com
… Currently, the goal of chronic myeloid leukemia (CML) treatment is normal survival and good
quality of life without life-long treatment, namely, “treatment-free remission” (TFR). At present…

[HTML][HTML] … immune transcriptomics identify distinct profiles in patients with chronic myeloid leukemia receiving tyrosine kinase inhibitors with or without interferon-α

R Alves, SEB McArdle, J Vadakekolathu… - Journal of Translational …, 2020 - Springer
Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder characterized by the
presence of the oncogenic BCR-ABL1 fusion gene derived from the reciprocal translocation …

Interferon-α as maintenance therapy can significantly reduce relapse in patients with favorable-risk acute myeloid leukemia

H Jiang, XH Liu, J Kong, J Wang, JS Jia… - Leukemia & …, 2021 - Taylor & Francis
… of interferon-α (IFN-α) as maintenance therapy in patients with favorable-risk acute myeloid
leukemia … : 42 patients who received IFN-α maintenance therapy and 42 patients who did not (…

[HTML][HTML] … pegylated interferon α (Peg-IFN) induction and nilotinib or Peg-IFN maintenance therapy for newly diagnosed BCR-ABL1 positive chronic myeloid leukemia …

A Hochhaus, A Burchert, S Saussele, GM Baerlocher… - Blood, 2019 - Elsevier
… -IFN) 30-50µg/week as first line therapy for chronic myeloid leukemia (CML) patients (pts)
in chronic phase and discontinuation of therapy after Peg-IFN maintenance (Figure). Methods…

Interferon-α Based Individualized Treatment of a High Risk Chronic Myelogenous Leukemia Patient Harboring T315I Mutation.

X Li, J Liu, Y Zeng, J Zhang, L Zhang - Clinical Laboratory, 2018 - search.ebscohost.com
… We report a high risk chronic myelogenous leukemia (CML) patient harboring the T315I
mutation treated by Interferon-α (INF-α) solo and subsequently combined with dasatinib. …

Analysis of the Clinical Significance and Safety of Interferon in the Treatment of Chronic Myeloproliferative Tumors

F Yin, J Yin, W Xu, S Li, W Zhang… - Journal of Oncology, 2022 - Wiley Online Library
… effect of interferon-α (IFN-α) in the treatment of MPN has … reticulum staining, or acute myeloid
leukemia (AML) caused by … MPNs include chronic myelogenous leukemia (CML), PV, ET…

Safety and efficacy of the combination of pegylated interferon-α2b and dasatinib in newly diagnosed chronic-phase chronic myeloid leukemia patients

H Hjorth-Hansen, J Stentoft, J Richter, P Koskenvesa… - Leukemia, 2016 - nature.com
… ) and interferon-α have antileukemic and immunostimulatory effects and induce deep
responses in chronic myeloid leukemia (CML). We assigned 40 newly diagnosed chronic-phase …

Discontinuation of alpha-interferon treatment in patients with chronic myeloid leukemia in long-lasting complete molecular response

R Latagliata, A Romano, M Mancini… - Leukemia & …, 2016 - Taylor & Francis
… discontinuation, 23 patients with chronic myeloid leukemia (CML) in stable complete molecular
response (CMolR) with IFN were revisited. After a median IFN treatment of 105.8 months (…

[HTML][HTML] Preemptive interferon-α therapy could protect against relapse and improve survival of acute myeloid leukemia patients after allogeneic hematopoietic stem …

MZ Shen, XH Zhang, LP Xu, Y Wang, CH Yan… - Frontiers in …, 2022 - frontiersin.org
… -HSCT) recipients, preemptive interferon-α (IFN-α) therapy is considered as a useful method
… assess the long-term efficacy of preemptive IFN-α therapy in acute myeloid leukemia (AML) …

Novel therapeutic approaches in chronic myeloid leukemia

NÖ Yurttaş, AE Eşkazan - Leukemia Research, 2020 - Elsevier
… The tyrosine kinase inhibitors (TKIs) have revolutionized the management of chronic myeloid
leukemia (CML) and BCR-ABL1 inhibitors form the mainstay of CML treatment. Although …