… Interleukin 12 (IL-12) family cytokines are secreted proteins that regulate immune responses.
Each family member is a heterodimer and nature uses shared building blocks to assemble …

… One important group of cytokines are interleukins, in which the twelfth to be described in
1989 was Interleukin-12 (IL-12). In more than three decades, numerous papers have reported …

… IL-6/IL-12 cytokines are key regulators of the immune system. They have pleiotropic functions
and play critical roles in multiple immune … 12 type cytokines site 1 is formed by the interface …

… roles in multiple cytokine signals involved in innate and acquired immunity. Immunity 25,
745–… Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. …

… High-resolution structures of cytokine:receptor complexes allow to rationally engineer
binding interfaces for desired properties. Thus far, the best available cryo-EM structure of the …

… -23p19 substitutions within its binding interface to hIL-23R … cytokines. The p40 subunit is
similar in the domain structure of typical class I cytokine receptors such as the nonsignaling IL-6 …

… Interleukin-12 (IL-12) and IL-23 are heterodimeric cytokines … We targeted the shared IL-12Rβ1/p40
interface to design a … + T cells but impaired cytokine production from natural killer (NK) …

… cytokine, plays pivotal roles in pro-inflammatory T helper 17 cell responses linked to
autoimmune and inflammatory … receptor (IL-23R) and interleukin-12 receptor subunit β1 (IL-12Rβ1), …

… Interleukin-12 (IL12) is a pleiotropic cytokine that stimulates both the adaptive and innate
immune … this cytokine is an ideal candidate for tumour immunotherapy [8]. However, despite the …

… family cytokines also show indispensable functions in immune … on immune functions and
structures of different cytokines in … The site I interface is characterized by extensive interactions …