Predicting Inhaled Drug Dose Generated by Mesh Nebulizers

YC Hsu, HH Li, LC Chiu, WC Chiang… - Journal of Aerosol …, 2023 - liebertpub.com
Intra-subject variability in lung dose in healthy volunteers using five conventional portable
inhalers. J Aerosol Med 2004;17:231–238; doi: 10.1089/jam.2004.17.231 Link, Google …

Can pharmacokinetic studies assess the pulmonary fate of dry powder inhaler formulations of fluticasone propionate?

G Hochhaus, MJ Chen, A Kurumaddali, U Schilling… - The AAPS journal, 2021 - Springer
… :water at ratio of 50:5:45 %v/v as mobile phase) was used for … in the lung doses received
by the healthy volunteers when … of C to assess intra-subject variability) in separate study …

A new method for measuring lung deposition efficiency of airborne nanoparticles in a single breath

JKF Jakobsson, J Hedlund, J Kumlin, P Wollmer… - Scientific Reports, 2016 - nature.com
… the inhaled particle dose has been substantial 5,10 . … parameters for measurements on
human subjects. A second aim is to … variability was significantly higher than the intra-subject

[PDF][PDF] Bioequivalence of two formulations of salmeterol xinafoate/fluticasone propionate HFA pMDI in healthy volunteers

M Garg, R Naidu, A Birhade, K Iyer, R Jadhav… - J. Bioequiv …, 2017 - academia.edu
… evaluated lung deposition of salmeterol after a single dose 50… The mobile phase comprised
of mixture of Acetonitrile, 5 mM … , 90% CI, and intra subject coefficient of variation of test and …

[PDF][PDF] The Practical use of the Multiple Breath Washout Test in Children: Biological variability in health and

H Sheridan - core.ac.uk
… More portable, less expensive equipment has now been … in healthy subjects but in longer
tests in diseased lungs may cause … They found that in school aged children the intra subject LCI …

Estimation of respiratory variables from thoracoabdominal breathing distance: a review of different techniques and calibration methods

A Houssein, D Ge, S Gastinger… - Physiological …, 2019 - iopscience.iop.org
… is restricted to healthy subjects and laboratory conditions. … analysed breaths, and intra-subject
discrepency with different … minute ventilation and lung deposited dose in commuting …

[PDF][PDF] Mephedrone: a single-dose administration study to determine human pharmacokinetics after nasal insufflation and to detect mephedrone and its metabolites in …

J Czerwinska - 2020 - kclpure.kcl.ac.uk
… six healthy male volunteers was performed to determine the distribution and pharmacokinetics
of mephedrone and its metabolites in conventional (… Inter- and intra-subject variability was …

Pharmacokinetics and pharmacodynamics of high doses of inhaled dry powder drugs

MK Hatipoglu, AJ Hickey, L Garcia-Contreras - International journal of …, 2018 - Elsevier
… few seconds, using a portable, easy to use device that would … to assess the intra-subject
variability and periods 4 and 5 to … in 20 healthy volunteers using single escalating doses of …

… bioequivalence, and safety studies of gefitinib tablet formulations: a randomized, open-label, two-period, two-sequence crossover study in Chinese healthy volunteers

P Du, Z Zhao, W Yu, R Zhao, H Liu, P Li, L Liu - Journal of Drug Delivery …, 2023 - Elsevier
… for treatment of non-small cell lung cancer (NSCLC) in February 2005. … The intra-subject
variability (intra-CV) for gefitinib is … Mobile phase for gradient elution composed of water (A, 0.4% …

… study of a telmisartan/S-amlodipine fixed-dose combination (CKD-828) formulation and coadministered telmisartan and S-amlodipine in healthy subjects

WY Kang, SJ Seong, B Ohk, MR Gwon… - Drug Design …, 2018 - Taylor & Francis
… The residue was reconstituted with 150 µL of the mobile phase, … conventional BE range of
0.800–1.250; 2) if the intrasubject … to determine the true intra-subject variability for the T and R …