… crest signature and enrichment of pigment-associated gene sets. … L-tyrosine and L-DOPA
not only serve as substrate and … and 5-S-cysteinyldopa become prooxidants in melanoma cells …

… This review goes from the evidence in the formation of … are not able to metabolize these
conjugates intracellularly, … in the substantia nigra and Cys-DOPA/DOPA in the putamen of the …

… Both elements are necessary for the pigment cell specific … However, JNK-mediated
suppression of pigmentation by … μL (1.5 μg/μL) of cell lysate and 10 μL of L-DOPA (10 mM), was …

… in pigmented cell during TPE-PDT evidenced by the cell … The high level of pigmentation
in melanoma has made it … (L-DOPA) and oxidation of L-DOPA to DOPA-quinone. Due to the …

… (DOPA) and generate dopaquinone [1]. … the melanosomes changes to ellipsoid, but
pigmentation is still absent [10,… , which is the main regulator of intracellular membrane trafficking …

… Melanin represent a group of natural pigments with essential … and forms dopachrome and
DOPA. Further, dopachrome is … Next, 5-S-cysteinyldopa is transformed into quinoline and …

… based on their formation process in the living … to pigments formed via intracellular processes
in humans and animals whereas the word allomelanins to pigments formed via extracellular …

… other cells [26], suggesting extracellular … formation increases with age in the substantia
nigra, and healthy older adults at death have these neurons intact loaded with this dark pigment. …

… intracellular and intercellular signalling pathways that regulate … Dopachrome formation
was monitored by measuring … shown to inhibit the oxidation of l-dopa by tyrosinase, and the 3-…

… pigmented patterns (different grades of brown pigmentation), … dihydroxyphenylalanine (L-DOPA)
and subsequent reaction … immediately reacts with it to form 5-S-cysteinyldopa or 5-S-…