… a role in contributing to the development of gastric ulcers such as the generation of reactive
oxygen species (… tissue; COX-1 is involved in protecting the gastric mucosa while COX-2 is …

… , a major source of reactive oxygen species (ROS) [7]. … whereas pretreatment with melatonin
protect the cells against … role in forced swim stress mediated acute gastric ulceration. …

… (12), and prevents acute gastric ulcers resulted from stress. These effects can be done
through direct reactive oxygen species/reactive nitrogen species (ROS/RNS) detoxification, …

… The antioxidant properties of melatonin in the digestive system especially in protection of …
resulted in a marked increase in the activity of GSH which has a major role in lowering …

… role of gastric anti-oxidant enzymes, luminal mucosa zinc level and gastric mucus cell counts
in the anti- ulcer … Assuming gastrointestinal melatonin is involved in the local protection, it is …

… Melatonin has been shown to be a potent reactive oxygen … to the protection of the
gastrointestinal mucosa [18, 19]. … NF-κB plays an active role in ulcer healing process [41] and NF-…

… role of MEL in the protection and/or healing of reflux esophagitis in patients and in experimental
animals … ethanol-induced gastric ulcers treated with MEL 30 min before ulcer induction. …

… gastric ulceration by a mechanism independent of gastric acid … plays a role as an inhibitor
in the regulation of gastric acid … worsen nor protect against aspirin-induced gastric lesions in …

… Moreover, the production of reactive oxygen species (ROS) is … damage was protected
significantly better by melatonin-loaded … the pivotal role of MMPs in gastric ulcers. However, the …

… , circadian rhythm regulation, cardiovascular protection, etc [18,… including gastric ulcers,
melatonin prevented gastric lesions by … Reactive oxygen species (ROS) produced under hypoxia …