… Structural analyses of ferroportin indicate that there are two divalent metal-binding sites, …
the ubiquitination of the lysine-rich cytoplasmic segment connecting the two 6-helix domains of …

… the iron efflux from cells [2]. Hepcidin itself does not bind iron but has two distinct metal-binding
sites with a potentially high affinity for other metal ions. One of these sites is its N-terminal …

… findings in iron biology, deregulation of the hepcidin-ferroportin axis in iron disorders and how
… The metal transporter DMT1 takes up ferrous iron, reduced by DCYTB, on the luminal side …

… apical membrane via divalent metal transporter 1 (DMT1), … significant role of hepcidin in
the iron homeostasis and as an … with a rare vicinal disulfide connection at Cys 4 –Cys 5 [23]. …

… As a transition metal with two major biological oxidation states, iron is also … hepcidin synthesis
in response to inflammatory cytokines. Our laboratory recently demonstrated that hepcidin …

… showed that ad-hepcidin and hepcidin peptide reduced brain iron uptake by decreasing …
So, how could hepcidin presence during ICH cause opposite results? During ICH brain iron is …

… Iron is an essential trace metal involved in oxygen transport, cellular metabolism, DNA … The
initial connection between hepcidin regulation and the TGF-β superfamily pathway was made …

… that hepcidin inhibited the iron export activity of endogenous Fpn. This result was consistent
with our observation that hepcidin incubation for 1 hour inhibited the export of iron-55 from …

… -3 (STEAP3), 55 which then passes through divalent metal transporter-1 (DMT1), Tf is expelled
from … TfR1, being so tightly connected to hepcidin expression is a useful marker, though …

… As predicted by the model, we also experimentally demonstrated that hepcidin can
function by occluding Fpn and preventing iron export even in the absence of endocytosis. …