… cancer prevention. Plants contain numerous phytonutrient secondary metabolites shown to
modulate COX-2… a given disease, but many collateral proteins feed into this defined pathway …

… (COX-2) that were developed in order to avoid the side effects of non-selective inhibitors of
COX-1. Thus, the present study aims to identify new selective chemical entities for the COX-2 …

… the inflammatory COX-2 while circumventing inhibition of the COX-1 isoform. While … COX-2
inhibitors may provide an effective means for pain relief, targeting the inflammatory COX-2 …

… of “drug holidays” and collateral sensitivity, … COX-2 expression, forming a feedback loop
[98]. NSAIDs may thus reverse resistance to molecular targeted therapy by targeting the COX-2 …

… tumor excision with minimal collateral damage and can … cancer progression as supported
by several COX-2-selective inhibitors with high efficacy as anti-inflammatory, cancer preventive…

… COX-2 is primarily activated in response to inflammatory stimuli; deletion of the COX-2
gene or selective COX-2 … The fickle nature of SCI is a result of the numerous collateral blood …

… ROS in cancer prevention and therapy, but also summarize the relevant small molecule
interventions and envision the future perspectives of ROS-targeted cancer … -2 (COX-2) inhibitor; …

… components and is an integral cause of the collateral tissue damage associated with
inflammation. In order to limit that collateral damage, host cells and fluids are equipped with …

… Aims & Methods: We aimed to investigate whether cyclooxygenase-2 (COX-2) is involved
as a contributing factor in the pathological process of splenomegaly in cirrhotic rats. Thirty-six …

… genes, one set for COX-2 correlated genes in differentiated (… in tumors could be a result of
collateral damage due to the … strong potential for breast cancer prevention and therapy. The …