Effect of isoorientin on intracellular antioxidant defence mechanisms in hepatoma and liver cell lines

L Yuan, J Wang, W Wu, Q Liu, X Liu - Biomedicine & Pharmacotherapy, 2016 - Elsevier
… Interestingly, in a human hepatoblastoma cancer cell line (HepG2), isoorientin increased …
rat liver cells (BRL-3A), isoorientin protected the cells against hydrogen peroxide-induced

Isoorientin attenuates benzo[a]pyrene-induced liver injury by inhibiting autophagy and pyroptosis in vitro and vivo

X Li, S He, C Gao, H Deng, Y Liu, C Li… - Food and Agricultural …, 2019 - Taylor & Francis
… Our previous studies also found that ISO could protect BRL-3A buffalo rat liver cells from H
2 O 2 -induced apoptosis by reducing NO production and elevating T-SOD levels (Yuan et al., …

Isoorientin prevents hyperlipidemia and liver injury by regulating lipid metabolism, antioxidant capability, and inflammatory cytokine release in high-fructose-fed mice

L Yuan, X Han, W Li, D Ren, X Yang - Journal of agricultural and …, 2016 - ACS Publications
… proliferation of human hepatoblastoma cancer cells by inducing apoptosis and autophagy.
(17, 18) ISO is able to protect liver cells against hydrogen peroxide-induced oxidation stress. (…

Isoorientin attenuates doxorubicin-induced cardiac injury via the activation of MAPK, Akt, and Caspase-dependent signaling pathways

S Li, H Liu, Z Lin, Z Li, Y Chen, B Chen, L Huang, X Lin… - Phytomedicine, 2022 - Elsevier
… For the first time, we report that: ISO protects cardiomyocytes from chemotherapy without …
flavonoid isoorientin (ISO) combined with doxorubicin (DOX) on the proliferation of tumor cells

Isoorientin reverses lung cancer drug resistance by promoting ferroptosis via the SIRT6/Nrf2/GPX4 signaling pathway

S Feng, Y Li, H Huang, H Huang, Y Duan… - European Journal of …, 2023 - Elsevier
… of isoorientin (IO) and DDP treatment resulted in a significant decrease in the viability of
drug-resistant cells, a … It protects cells from oxidative stress by regulating endogenous antioxidant …

Hepatoprotective Effects of Flavonoids against Benzo [a] Pyrene-Induced Oxidative Liver Damage along Its Metabolic Pathways

M Kim, SC Jee, JS Sung - Antioxidants, 2024 - mdpi.com
… GPX exhibits peroxide activity, protecting against oxidative … [a]P and ethanol on primary rat
hepatocytes leads to plasma … Moreover, isoorientin demonstrated promise in alleviating B[a…

Protective effect of procyanidin B2 on hydrogen peroxide (H2O2)-induced oxidative damage in MCF-7 cells

J Tan, P Li, Q Li, J Tang, H Xue - Applied Biological Chemistry, 2020 - Springer
… Our findings suggested that PCB 2 protected MCF-7 cells against oxidative damage
through … cytoprotective effects against ROS in HepG2 cells, HUVECs and BRL-3A cells [28,29,30]. …

Cyanidin-3-glucoside prevents hydrogen peroxide (H2O2)-induced oxidative damage in HepG2 cells

J Tan, P Li, H Xue, Q Li - Biotechnology Letters, 2020 - Springer
… had been concentrated on hunting for natural active ingredients with liver protective
potential, which could scavenge excess free radicals and protect cells from oxidative damage. …

Effects of natural flavonoid isoorientin on growth performance and gut microbiota of mice

L Yuan, X Li, S He, C Gao, C Wang… - Journal of agricultural …, 2018 - ACS Publications
… damages in rats (9) and hydrogen-peroxide-induced oxidation stress in HL-7702 liver cells
(10) … Lipocalin 2 protects from inflammation and tumorigenesis associated with gut microbiota …

Sasa borealis Ethanol Extract Protects PC12 Neuronal Cells against Oxidative Stress

MH Kang, YJ Ji, YM Han, GY Jang, DH Kim, JH Lee… - Applied Sciences, 2022 - mdpi.com
… In conclusion, SBE with high levels of phenolic compounds such as isoorientin … , isoorientin
attenuates the oxidative damage induced by oleic acid in buffalo rat liver 3A (BRL-3A) cells […