A large-scale multicenter retrospective study on nephrotoxicity associated with empiric broad-spectrum antibiotics in critically ill patients
… critically ill patients in the ICU and used a more stringent definition of AKI, defined as Kidney
Disease: … ORs and 95% CIs were calculated to assess the risk of the primary and secondary …
Disease: … ORs and 95% CIs were calculated to assess the risk of the primary and secondary …
Incidence of acute kidney injury among critically ill patients with brief empiric use of antipseudomonal β-lactams with vancomycin
DJ Schreier, KB Kashani, A Sakhuja… - … Infectious Diseases, 2019 - academic.oup.com
… We also compared the risk of persistent kidney dysfunction, … broad-spectrum antibiotic
combinations in critically ill patients. … Secondary end points included incidence of maximum-stage …
combinations in critically ill patients. … Secondary end points included incidence of maximum-stage …
Pharmacokinetic and pharmacodynamic considerations of antibiotics of last resort in treating gram-negative infections in adult critically ill patients
MS Heavner, KC Claeys, AM Masich… - … infectious disease …, 2018 - Springer
… in clinical practice secondary to its broad spectrum of activity, … therapy in critically ill patients
has fallen out of favor due to a … in critically ill patients, and the patients’ renal function should …
has fallen out of favor due to a … in critically ill patients, and the patients’ renal function should …
The use and risks of antibiotics in critically ill patients
… compared early use of broad-spectrum antibiotics (imipenem/… fluctuations in renal function
in critically ill patients mean that … hypoalbuminemia secondary to critical illness and antibiotic …
in critically ill patients mean that … hypoalbuminemia secondary to critical illness and antibiotic …
Critically Ill Health Care-Associated Urinary Tract Infection: Broad vs. Narrow Antibiotics in the Emergency Department Have Similar Outcomes
KJ Kooda, M Rudis, K Mara, C Clements… - The Journal of …, 2021 - Elsevier
… empiric therapy selection and secondary outcomes, including … ESBL coverage in all critically
ill patients presenting with HCA … Empiric broad-spectrum coverage did not affect outcome in …
ill patients presenting with HCA … Empiric broad-spectrum coverage did not affect outcome in …
Bloodstream infections in critically ill patients: an expert statement
… with systemic signs of infection and may be either secondary … linked with an increased
hazard of acute renal failure at the … the broad-spectrum antimicrobial that was initially started. …
hazard of acute renal failure at the … the broad-spectrum antimicrobial that was initially started. …
A multidisciplinary antimicrobial stewardship programme safely decreases the duration of broad-spectrum antibiotic prescription in Singaporean adult renal patients
Y Cai, PY Shek, I Teo, SSL Tang, W Lee… - International journal of …, 2016 - Elsevier
… Patients with chronic kidney disease have increased risk of infections. Thus, physicians may
favour prolonged broad-spectrum antibiotic use. … antibiotic use was secondary to antibiotics …
favour prolonged broad-spectrum antibiotic use. … antibiotic use was secondary to antibiotics …
Ensuring target concentrations of antibiotics in critically ill patients through dose adjustment
J Gorham, FS Taccone, M Hites - Expert Opinion on Drug …, 2022 - Taylor & Francis
… disorders, either secondary … renal clearance is challenging due to the fact that we have
to take into account non-CRRT CL (renal clearance due to residual renal function plus non-renal …
to take into account non-CRRT CL (renal clearance due to residual renal function plus non-renal …
Antibiotic therapy in the critically ill with acute renal failure and renal replacement therapy: a narrative review
… antibiotics posology for critically ill patients undergoing CRRT. … They have a broad spectrum
with action also towards intracellular … Secondary outcomes included the achievement of …
with action also towards intracellular … Secondary outcomes included the achievement of …
Antibiotic stewardship in sepsis management: toward a balanced use of antibiotics for the severely ill patient
JJ De Waele, S Dhaese - Expert review of anti-infective therapy, 2019 - Taylor & Francis
… in critically ill patients carry a high morbidity and mortality rate. Given the impact of early and
broad-spectrum … such as acute kidney injury, anaphylaxis, and development of Clostridium …
broad-spectrum … such as acute kidney injury, anaphylaxis, and development of Clostridium …