[HTML][HTML] Lipoprotein (a) beyond the kringle IV repeat polymorphism: the complexity of genetic variation in the LPA gene
S Coassin, F Kronenberg - Atherosclerosis, 2022 - Elsevier
… the apolipoprotein E polymorphism and the kringle-IV repeat polymorphism of the LPA
gene … the commonly assumed inverse relationship between apo(a) isoform size and Lp(a) …
gene … the commonly assumed inverse relationship between apo(a) isoform size and Lp(a) …
Human genetics and the causal role of lipoprotein (a) for various diseases
F Kronenberg - Cardiovascular drugs and therapy, 2016 - Springer
… under strict genetic control by the LPA gene locus and here especially by a size polymorphism
of apo(a) caused by a variable number of kringle IV (KIV) repeats in the LPA gene [1, 6]. …
of apo(a) caused by a variable number of kringle IV (KIV) repeats in the LPA gene [1, 6]. …
Apolipoprotein (a) kringle-IV type 2 copy number variation is associated with venous thromboembolism
E Sticchi, A Magi, PR Kamstrup, R Marcucci, D Prisco… - PLoS …, 2016 - journals.plos.org
… the role of LPA gene KIV-2 size polymorphism and single nucleotide polymorphisms (SNPs)
(… Our major finding is that low LPA KIV-2 repeat number is significantly and independently …
(… Our major finding is that low LPA KIV-2 repeat number is significantly and independently …
Role of lipoprotein (a) and LPA KIV2 repeat polymorphism in bicuspid aortic valve stenosis and calcification: a proof of concept study
… and LPA Kringle IV type 2 (KIV-2) size polymorphism in … between Lp(a) plasma levels, LPA
KIV-2 size polymorphism, reflecting a variable number of kringle (K) IV type 2 apolipoprotein (…
KIV-2 size polymorphism, reflecting a variable number of kringle (K) IV type 2 apolipoprotein (…
Elevated Lipoprotein(a) Levels, LPA Risk Genotypes, and Increased Risk of Heart Failure in the General Population
PR Kamstrup, BG Nordestgaard - JACC: Heart Failure, 2016 - jacc.org
… by polymorphisms in the LPA gene coding for apolipoprotein(a). The kringle IV type 2 (KIV-2)
repeat polymorphism is particularly important; it determines apolipoprotein(a) size that …
repeat polymorphism is particularly important; it determines apolipoprotein(a) size that …
Lipoprotein (A) And Risk Of Ischemic Stroke In The General Population
A Langsted, BG Nordestgaard… - …, 2019 - atherosclerosis-journal.com
… (a), LPA kringle-IV type 2 (KIV-2) number of repeats, and LPA … , the kringle IV-2 repeats, which
give rise to size heterogeneity… quantitation of apo(a) independent of its size polymorphism. …
give rise to size heterogeneity… quantitation of apo(a) independent of its size polymorphism. …
Lipoprotein (a): a unique independent risk factor for coronary artery disease
A Manocha, LM Srivastava - Indian journal of clinical biochemistry, 2016 - Springer
… The LPA gene codes for apo(a) whose genetic heterogeneity … between apoB 100 in LDL
and kringle IV in apo(a) [44]. The … inverse relationship between apo(a) size polymorphism and …
and kringle IV in apo(a) [44]. The … inverse relationship between apo(a) size polymorphism and …
Low lipoprotein (a) levels and risk of disease in a large, contemporary, general population study
A Langsted, BG Nordestgaard… - European heart …, 2021 - academic.oup.com
… of varying size, apolipoprotein(a), covalently bound. … variation in the apolipoprotein(a)-coding
LPA gene, may vary … in 70 286, LPA kringle-IV type 2 (KIV-2) number of repeats genotype …
LPA gene, may vary … in 70 286, LPA kringle-IV type 2 (KIV-2) number of repeats genotype …
Prevalence and influence of LPA gene variants and isoform size on the Lp (a)-lowering effect of pelacarsen
E Karwatowska-Prokopczuk, N Clouet-Foraison, S Xia… - Atherosclerosis, 2021 - Elsevier
… apolipoprotein(a) that included 455 patients. Common … low number of Kringle IV type 2 (KIV
2 ) repeats, which translate … , mainly represented by single nucleotide polymorphisms (snps) …
2 ) repeats, which translate … , mainly represented by single nucleotide polymorphisms (snps) …
Structure, function, and genetics of lipoprotein (a)
K Schmidt, A Noureen, F Kronenberg… - Journal of lipid …, 2016 - ASBMB
… multiallelic copy number variation in the LPA gene and the strong association with coronary
… of the Lp(a)/LPA trait, as well as aspects of genetic epidemiology. It highlights the role of …
… of the Lp(a)/LPA trait, as well as aspects of genetic epidemiology. It highlights the role of …