… for storage. On the contrary, during fasting PPARα activity shifts to fatty acid uptake and fatty
acid β-oxidation. In … hepatic lipid accumulation owing to inhibition of fatty acid uptake and β-…

… LXRs also regulate fatty acid metabolism by controlling the … acid β-oxidation in adipose
tissues 73,74 . On a high-… fat storage in adipose tissues. Moreover, ob/ob mice lacking …

… increase FA oxidation in the skeletal muscle, reduce fat gain … Activation of LXR can lead to
increased liver fat deposition … reducing T0901317-mediated lipid accumulation in the liver [215]…

… (oxidized cholesterol derivatives; Baranowski 2008; Peet et al. 1998; Zelcer and Tontonoz
2006). The LXRs maintain normal cholesterol balance … the amount of fat storage (observed as …

… the supraphysiological accumulation of free fatty acids in the serum of LXR DKO mice …
activation of LXR increases adipose tissue lipolysis and fatty acid β-oxidation (37). We show …

… accumulation of lipids, resulting in the formation of lipid droplets within hepatocytes. This
accumulation results from an imbalance between lipid … receptor (LXR), sterol regulatory element-…

… is regulated by oxysterols, the oxidized forms of cholesterol. Described in the late 1990s as
lipid sensors, both LXRs regulate cholesterol and fatty … increases Renin accumulation, LXRβ …

… While largely identified by the accumulation of lipid-laden … in nitric oxide production by
endothelial nitric oxide synthase (… of nitric oxide, or even a production of oxidative species that …

… LXR ligands will better inform our understanding of its function in development and homeostasis
and provide insight into the role of LXR in disease states. Liver X receptors (LXRs) are …

… to fat accumulation, thereby leading to hepatic metabolic impairment and NASH progression
[10]. Moreover, oxidative stress-related oxidized … LXRs are vital for controlling lipid …