… deficiency ameliorates hepatic steatosis by reducing lipogenesis and enhancing fatty acid β-oxidation through AMPK and PGC-1α induction in high-fat diet-fed mice
T Dusabimana, EJ Park, J Je, K Jeong, SP Yun… - International Journal of …, 2021 - mdpi.com
… lipid accumulation in the liver, where lipid uptake and de novo synthesis surpass lipid oxidation
… In NAFLD, hepatic uptake and de novo lipogenesis are increased, while lipid oxidation is …
… In NAFLD, hepatic uptake and de novo lipogenesis are increased, while lipid oxidation is …
Neuroendocrine regulation of metabolism
… accumulation of intracellular cholesterol oxides, LXRs activate … , LXRs are also intimately
involved in the control of hepatic … the brain and is induced by oxidative stress 55. Glucose has …
involved in the control of hepatic … the brain and is induced by oxidative stress 55. Glucose has …
[HTML][HTML] Dingxin Recipe IV attenuates atherosclerosis by regulating lipid metabolism through LXR-α/SREBP1 pathway and modulating the gut microbiota in ApoE …
Y Zhang, Y Gu, Y Chen, Z Huang, M Li, W Jiang… - Journal of …, 2021 - Elsevier
… It has been claimed that Erysipelotrichaceae may promote cholesterol accumulation by
Trimethylamine N-oxide production. The reduction of Erysipelotrichaceae may be beneficial to …
Trimethylamine N-oxide production. The reduction of Erysipelotrichaceae may be beneficial to …
Lipid metabolism in colon cancer: role of liver X receptor (LXR) and stearoyl-CoA desaturase 1 (SCD1)
E Piccinin, M Cariello, A Moschetta - Molecular aspects of medicine, 2021 - Elsevier
… Therefore, strategies aimed at limiting lipid accumulation are now under development in … ,
by increasing lipogenesis, reducing fatty acid oxidation, and modulating intracellular signaling. …
by increasing lipogenesis, reducing fatty acid oxidation, and modulating intracellular signaling. …
Oxysterols and bile acid act as signaling molecules that regulate cholesterol homeostasis: Nuclear receptors LXR, FXR, and fibroblast growth factor 15/19
K Fon Tacer - Mammalian Sterols: Novel Biological Roles of …, 2020 - Springer
… oxidative species-induced chemical oxidation. Naturally occurring oxysterols that are also
LXR … conditions cause the accumulation of desmosterol that acts as a specific LXR activator [66…
LXR … conditions cause the accumulation of desmosterol that acts as a specific LXR activator [66…
Fatty acid handling in mammalian cells
R Lehner, AD Quiroga - Biochemistry of lipids, lipoproteins and membranes, 2021 - Elsevier
… regulating fat oxidation. Liver-specific ACC1 and ACC2 double knockout mice have increased
hepatic lipid levels and this lipid accumulation … regulated by SREBP-1c, LXR and ChREBP…
hepatic lipid levels and this lipid accumulation … regulated by SREBP-1c, LXR and ChREBP…
Loss of ULK1 increases RPS6KB1-NCOR1 repression of NR1H/LXR-mediated Scd1 transcription and augments lipotoxicity in hepatic cells
… ULK1 that regulates NR1H/LXR signaling, Scd1 expression, and intracellular lipid homeostasis
… methods: β-oxidation of FAs in mitochondria and/or storage of FAs within neutral LD(s) (…
… methods: β-oxidation of FAs in mitochondria and/or storage of FAs within neutral LD(s) (…
Loss of perilipin 2 in cultured myotubes enhances lipolysis and redirects the metabolic energy balance from glucose oxidation towards fatty acid oxidation
YZ Feng, J Lund, Y Li, IK Knabenes, SS Bakke… - Journal of lipid …, 2017 - ASBMB
… of these two separate oxidative pathways, competitive and feedback interactions among
their various substrates and products also directs glucose/FA oxidative balance and may be …
their various substrates and products also directs glucose/FA oxidative balance and may be …
Lipid metabolism and the liver
M Enjoji, M Kohjima, M Nakamuta - The Liver in Systemic Diseases, 2016 - Springer
… of FA oxidation and the formation of ketone bodies. Specifically, PPARα upregulates the
expression of genes involved in mitochondrial and peroxisomal β-oxidation, … fat storage [25, 26]. …
expression of genes involved in mitochondrial and peroxisomal β-oxidation, … fat storage [25, 26]. …
TMEM135 is an LXR-inducible regulator of peroxisomal metabolism
BJ Renquist, TW Madanayake, JD Hennebold… - BioRxiv, 2018 - biorxiv.org
… target gene in mice (Fig S2), we used fasting to acutely induce hepatic fat accumulation.
The … Our data indicate that the LXRs can stimulate peroxisomal β-oxidation by increasing …
The … Our data indicate that the LXRs can stimulate peroxisomal β-oxidation by increasing …