… found to participate in the regulation of hepatic glucose metabolism, while LXR, FXR, PPARs,
… Fatty acids are oxidized or synthesized to triglycerides for storage or transported out of the …

… LXRs bind to LXRE located in regulatory regions of the LXR … of foam cells in the presence
of oxidized species of LDL (Paz-… is inhibited, and lipid accumulation is prevented by promoting …

… capacity for oxidative metabolism in healthy lipid homeostasis… In general, LXRs are key
regulators of lipid homeostasis and … adipose tissue exceeds its lipid storage capacity and TG non-…

… Because oxysterols are agonists for Liver X Receptors (LXRs), … This cholesterol in turn is
oxidized to oxysterols (Fig. 2), … alterations, cholesterol and lipid accumulation, might redefine …

… that LXR regulates lipogenesis during milk fat production in … and enhanced cytoplasmic
lipid droplet accumulation in the … The endogenous LXRs ligands are oxidative derivatives of …

… differences in LXR/SREBP-1-mediated regulation of gene … , no fat deposition was observed
in the livers of the control rats. … Several research groups have reported that oxidative stress …

… the regulation of cholesterol homeostasis and lipid synthesis (24, 25). LXRs control hepatic
… To determine whether altered FA oxidation contributes to the changes in hepatic TG content…

… as oxidized LDLs, are thought to participate in the formation of early atherosclerotic lesions
(accumulation of foam cells and fatty … As oxidized LDLs and oxidized lipids are present in …

The oxidative modification of the major cholesterol carrying lipoprotein, oxLDL, is a … hub for
protein folding and processing, lipid biosynthesis and calcium storage, thereby leading to ER …

… which leads to the decrease in free fatty acid (FFA) oxidation, which can stimulate de novo
… LXR expression has been correlated with the degree of hepatic lipid accumulation, as well …