[PDF][PDF] Activation of liver X receptor/retinoid X receptor pathway ameliorates liver disease in Atp7B−/− (Wilson disease) mice
JP Hamilton, L Koganti, A Muchenditsi… - …, 2016 - Wiley Online Library
… (17) We hypothesized that reductions in LXR/RXR function may … involve copper dependent,
nonenzymatic oxidation, and/or … T0901317-induced hepatic fat accumulation in mice. AAPS J …
nonenzymatic oxidation, and/or … T0901317-induced hepatic fat accumulation in mice. AAPS J …
[HTML][HTML] Tanshinone IIA downregulates lipogenic gene expression and attenuates lipid accumulation through the modulation of LXRα/SREBP1 pathway in HepG2 …
… acquisition, storage, export, and utilization as energy upon the oxidation of … In this study,
we found that the LXR agonist enhanced lipogenic genes and contributed to lipid accumulation …
we found that the LXR agonist enhanced lipogenic genes and contributed to lipid accumulation …
Silibinin capsules improves high fat diet-induced nonalcoholic fatty liver disease in hamsters through modifying hepatic de novo lipogenesis and fatty acid oxidation
CX Cui, JN Deng, L Yan, YY Liu, JY Fan, HN Mu… - Journal of …, 2017 - Elsevier
… hepatic fat accumulation compared with control hamsters, … , FA oxidation, FA uptake and
TG lipolysis. We thus further investigated the role of SC in regulating the four pathways of lipid …
TG lipolysis. We thus further investigated the role of SC in regulating the four pathways of lipid …
[HTML][HTML] Long non-coding RNA in liver metabolism and disease: current status
Y Zhao, J Wu, S Liangpunsakul, L Wang - Liver research, 2017 - Elsevier
… , fatty acid b-oxidation and thermogenesis. The maintenance of glucose homeostasis results
from the balance of glucose production and/or storage in … treated with LXR agonist GW3965, …
from the balance of glucose production and/or storage in … treated with LXR agonist GW3965, …
[HTML][HTML] Targeting liver X receptors for the treatment of non-alcoholic fatty liver disease
H Kim, C Park, TH Kim - Cells, 2023 - mdpi.com
… by inhibiting autophagy and lipophagy, leading to excessive fat accumulation in the liver [85]…
oxidation to lipid oxidation [86]. Collectively, LXRs contribute to the regulation of lipid …
oxidation to lipid oxidation [86]. Collectively, LXRs contribute to the regulation of lipid …
[HTML][HTML] Liver X receptors: a possible link between lipid disorders and female infertility
S Dallel, I Tauveron, F Brugnon, S Baron… - International Journal of …, 2018 - mdpi.com
… Furthermore, the oxidative stress seems to be higher in the … atypical LXR target gene, which
could explain how LXR could … into LXR-activating oxysterols induces a higher accumulation …
could explain how LXR could … into LXR-activating oxysterols induces a higher accumulation …
G0S2: A small giant controller of lipolysis and adipose-liver fatty acid flux
X Zhang, BL Heckmann, LE Campbell, J Liu - … Molecular and Cell Biology of …, 2017 - Elsevier
… processes including oxidative activity and lipid accumulation in … These side effects render
LXR agonists essentially useless … promotes TG deposition in response to LXR agonism has led …
LXR agonists essentially useless … promotes TG deposition in response to LXR agonism has led …
[HTML][HTML] Macrophage fatty acid metabolism and atherosclerosis: the rise of PUFAs
… did not affect lipid accumulation in tissue macrophages or the … , EPA and DHA derived oxidized
mediators and induces an … direct LXR targets, regulation of FADS1 and FADS2 by LXR is …
mediators and induces an … direct LXR targets, regulation of FADS1 and FADS2 by LXR is …
[HTML][HTML] Mongolian medicine in treating type 2 diabetes mellitus combined with nonalcoholic fatty liver disease via FXR/LXR-mediated P2X7R/NLRP3/NF-κB pathway …
S Bao, X Wang, Q Ma, C Wei, J Nan, W Ao - Chinese Herbal Medicines, 2022 - Elsevier
… results in TG accumulation in the liver and increases oxidative stress. Then… oxidation and
thereby increasing reactive oxygen species (ROS) production. ROS can attack unsaturated fatty …
thereby increasing reactive oxygen species (ROS) production. ROS can attack unsaturated fatty …
A biologically based model to quantitatively assess the role of the nuclear receptors liver X (LXR), and pregnane X (PXR) on chemically induced hepatic steatosis
C Bay, HA El-Masri - Toxicology letters, 2022 - Elsevier
… Additionally, imbalances between plasma free fatty acids and peripheral oxidative …
combinations of LXR and RXR agonists may cause synergistic effects for hepatic lipid accumulation. …
combinations of LXR and RXR agonists may cause synergistic effects for hepatic lipid accumulation. …