… were excluded from the experiment based on two criteria: (1) failure to meet acquisition
criteria within 14 cocaine self-administration sessions, and (2) loss of catheter patency. …

… study at various time points due to loss during or after … cocaine self-administration, or loss
of catheter patency. Information on mouse numbers from onset of the self-administration study …

… Second, intermittent and long access cocaine self-administration change the brain in very
… drug in the absence of apparent signs of tolerance to the reinforcing or incentive effects of …

… this, mice engineered to express cocaine-insensitive DATs … of cocaine that mimic patterns
of cocaine self-administration … In the absence of DATs, it is likely that DA clearance is largely a …

… to the primary target of cocaine, the dopamine transporter (DAT). … We further explored
whether lack of PICK1 affected cocaine’… We also observed reduced cocaine self-administration …

… to inhibiting the dopamine transporter (DAT), cocaine also … We constructed a functional but
cocaine-insensitive DAT mutant by … -CI mice with a drug self-administration paradigm showing …

… We found that stimulated dopamine release in the absence of cocaine was not related to Q 0
or P max (Figure 2a … Abolished cocaine reward in mice with a cocaine-insensitive dopamine …

… to cocaine’s effects at the dopamine transporter (DAT). However, Intermittent Access (IntA)
cocaine self-administration … self-administration experience in the absence of amphetamine. …

… reuptake leading to increased dopamine signaling. This action is thought to reflect binding
of cocaine to the dopamine transporter (DAT) to inhibit its function. However, cocaine is a …

… For this purpose, we used both loss- and gain-of-function … ], as well as cocaine-induced
locomotor stimulation [30] in rats. … operant ethanol self-administration in D2 receptor KO mice was …