Latent mutations in the ancestries of alleles under selection
WTL Fan, J Wakeley - Theoretical Population Biology, 2024 - Elsevier
We consider a single genetic locus with two alleles A 1 and A 2 in a large haploid
population. The locus is subject to selection and two-way, or recurrent, mutation. Assuming
the allele frequencies follow a Wright–Fisher diffusion and have reached stationarity, we
describe the asymptotic behaviors of the conditional gene genealogy and the latent
mutations of a sample with known allele counts, when the count n 1 of allele A 1 is fixed, and
when either or both the sample size n and the selection strength| α| tend to infinity. Our study …
population. The locus is subject to selection and two-way, or recurrent, mutation. Assuming
the allele frequencies follow a Wright–Fisher diffusion and have reached stationarity, we
describe the asymptotic behaviors of the conditional gene genealogy and the latent
mutations of a sample with known allele counts, when the count n 1 of allele A 1 is fixed, and
when either or both the sample size n and the selection strength| α| tend to infinity. Our study …
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