Central neural control of thermoregulation and brown adipose tissue

SF Morrison - Autonomic Neuroscience, 2016 - Elsevier
dorsomedial hypothalamus and dorsal hypothalamic area (DMH/DA). Preoptic WS neurons
provide inhibitory control of CVC by inhibiting CVC sympathetic … the increased sympathetic

[HTML][HTML] Traveling from the hypothalamus to the adipose tissue: the thermogenic pathway

C Contreras, R Nogueiras, C Diéguez, K Rahmouni… - Redox biology, 2017 - Elsevier
… the hypothalamus, and taking the sympathetic roads to reach … in in brown adipose tissue
(BAT) and white adipose tissue (… Leptin induces POMC expression increasing the release of …

GABAergic leptin receptor-expressing neurons in the dorsomedial hypothalamus project to brown adipose tissue-related neurons in the paraventricular nucleus of …

Y Jiang, K Rezai-Zadeh, LD Desmoulins… - Autonomic …, 2023 - Elsevier
… modulates the sympathetic outflow. … hypothalamic-pituitary-thyroid axis. A more recent
study demonstrated that bilateral leptin injection into the PVN of rats held at ~35 C increased

[HTML][HTML] Gsα deficiency in the dorsomedial hypothalamus leads to obesity, hyperphagia, and reduced thermogenesis associated with impaired leptin signaling

M Chen, EA Wilson, Z Cui, H Sun, YB Shrestha… - Molecular …, 2019 - Elsevier
leptin signaling along with increased expression of the leptin … key hypothalamic region
governing sympathetically mediated … Brown adipose tissue (BAT) is one of the major thermogenic …

[HTML][HTML] There and back again: leptin actions in white adipose tissue

N Martínez-Sánchez - International journal of molecular sciences, 2020 - mdpi.com
… to increased leptin levels, producing a phenomenon called “… two types of adipose tissue:
WAT and brown adipose tissue (… of leptin can excite the sympathetic tone innervating WAT, …

Leptin and brain–adipose crosstalks

A Caron, S Lee, JK Elmquist, L Gautron - Nature Reviews …, 2018 - nature.com
… mice increased fatty acid release 39 . Below, we discuss how … Brown adipose depots are
richly innervated by sympathetic … nucleus (ARC), dorsomedial hypothalamus (DMH), lateral …

Role of leptin in energy expenditure: the hypothalamic perspective

R Pandit, S Beerens, RAH Adan - American Journal of …, 2017 - journals.physiology.org
… system and brown adipose tissue (BAT) thermogenesis via the … different hypothalamic
nuclei, dorsomedial hypothalamus (… hypothalamus inhibit sympathetic outflow to brown adipose

Brown adipose tissue—a translational perspective

AC Carpentier, DP Blondin, F Haman… - Endocrine …, 2023 - academic.oup.com
sympathetic stimulation of intracellular triglyceride lipolysis. This lipolytic BAT response is
intertwined with that of white adipose (… be fully and selectively activated to increase the body’s …

[HTML][HTML] Leptin resistance and the neuro-adipose connection

A Barateiro, I Mahú, AI Domingos - Frontiers in endocrinology, 2017 - frontiersin.org
… in brown adipose tissue (BAT) and browning of WAT, via the activation of the sympathetic
The heart, kidney and muscle seem to be the major targets of increased sympathetic tone in …

[HTML][HTML] Incendiary leptin

P Seoane-Collazo, N Martínez-Sánchez, E Milbank… - Nutrients, 2020 - mdpi.com
… in the hypothalamus. However, it has also been demonstrated that leptin can stimulate (i)
thermogenesis in brown adipose tissue (… The increase of sympathetic tone induces a release of …