… support neoplastic cell survival and proliferation. This review focuses on the cellular and
molecular biology of microenvironment/leukemia interactions in acute lymphoblastic leukemia (…

… Possible strategies for therapeutic targeting of AML stem cells. The leukemic stem cells are
… Thus, the optimal strategy for therapeutic targeting of these stem cells will probably differ …

… Further, we note that all of the therapeutic strategies discussed in “LSC characteristics that
may provide opportunities for therapeutic targeting” are directed toward fully transformed AML …

… EMT aid in the generation of cells with stem cell characteristics … to maintenance makes
epigenetics a therapeutic target in CSCs. … promising drugs targeting this population of tumor cells. …

… leukemic cells and bone marrow (BM) cells in the leukemia BM microenvironment regulate
leukemia stem cell (LSC) … supporting the AML BM niche may yield novel therapeutic targets . …

… tools in treatment strategies. To this end, both the CSCs and the TME represent important
therapeutic targets. Emerging research has shown that CSC-targeted approaches have proven …

… S1P signaling has been highlighted as a potential therapeutic target in the treatment of
LSCs. Such an agent, S1PR3OE, has been shown to induce differentiation in HSCs, which may …

… therapeutic targets. In this review, we will discuss LSC biology in the context of their specific
microenvironment … LSC niche biology could pave the way for new therapies that target AML. …

… Consequently, the PD1-PDL1 axis has emerged as a highly promising target in CLL and …
become both a bio-marker and a therapeutic target. Engineering T cells to overcome the …

… pathways typical of the leukemic stem cells will be better understood. It is unlikely that a
single agent will be able to eliminate the leukemic stem cells. Targeted therapy will most likely …