New Bifunctional Chelator p-SCN-PhPr-NE3TA for Copper-64: Synthesis, Peptidomimetic Conjugation, Radiolabeling, and Evaluation for PET Imaging
… In order to identify their relative stability of the chelator-Fe(III) … internalized by B16F10 cells
within the first 15 min, and the … After removal of the surface-bound fraction, cell pellets were …
within the first 15 min, and the … After removal of the surface-bound fraction, cell pellets were …
Translational development of a Zr-89-labeled inhibitor of prostate-specific membrane antigen for PET imaging in prostate cancer
SM Vázquez, H Endepols, T Fischer… - Molecular Imaging and …, 2022 - Springer
… The only difference lies in the chelating agent for zirconium … radiolabeling procedure was
performed by adjusting the pH of … glycine (surface-bound), and 1 M NaOH (internalized fraction) …
performed by adjusting the pH of … glycine (surface-bound), and 1 M NaOH (internalized fraction) …
Preparation and evaluation of radiolabeled antibody recruiting small molecules that target prostate-specific membrane antigen for combined radiotherapy and …
AR Genady, N Janzen, L Banevicius… - Journal of Medicinal …, 2016 - ACS Publications
… (14-17) In addition, there are significant practical advantages to … The goal was to identify
compounds that had high affinity for … were used to calculate surface-bound and internalized …
compounds that had high affinity for … were used to calculate surface-bound and internalized …
CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity
ML Burr, CE Sparbier, YC Chan, JC Williamson… - Nature, 2017 - nature.com
… Here we identify the uncharacterized … antibody and allowed to internalize for 30 min at 37
C as described in a. Remaining cell-surface bound antibody was stripped by washing in pH 2.5 …
C as described in a. Remaining cell-surface bound antibody was stripped by washing in pH 2.5 …
Standardization of the [68Ga]Ga-PSMA-11 Radiolabeling Protocol in an Automatic Synthesis Module: Assessments for PET Imaging of Prostate Cancer
LL Fuscaldi, DV Sobral, ACR Durante, FF Mendonça… - Pharmaceuticals, 2021 - mdpi.com
… in this work—which provides further advantages for this product [25]. … In addition, in this case,
no significant difference was … and was internalized into the tumor cells according to in vitro …
no significant difference was … and was internalized into the tumor cells according to in vitro …
Screening and Preclinical Evaluation of Novel Radiolabeled Anti-Fibroblast Activation Protein-α Recombinant Antibodies
J Xu, S Li, S Xu, J Dai, Z Luo, J Cui, F Cai… - Cancer Biotherapy & …, 2023 - liebertpub.com
… FAPα, which is a cell surface-bound type II transmembrane … analysis, except a slight difference
between the uptake values of … with no internalization that limits their function for efficient …
between the uptake values of … with no internalization that limits their function for efficient …
Bivalent inhibitors of prostate-specific membrane antigen conjugated to desferrioxamine B squaramide labeled with zirconium-89 or gallium-68 for diagnostic imaging …
… 89 Zr is ideal for radiolabeling full antibodies (IgGs) because … A separate cohort of three
mice was harvested at 1 h post … Surface-bound and internalized fractions were expressed as …
mice was harvested at 1 h post … Surface-bound and internalized fractions were expressed as …
Novel “add-on” molecule based on Evans blue confers superior pharmacokinetics and transforms drugs to theranostic agents
… bars represent internalized 64 Cu-NMEB-RGD, and blue bars represent surface-bound 64
… These differences increased over time, and tumors of mice injected with 7.4 MBq of 90 Y-…
… These differences increased over time, and tumors of mice injected with 7.4 MBq of 90 Y-…
Fluorine-18 labeling of an anti-HER2 VHH using a residualizing prosthetic group via a strain-promoted click reaction: Chemistry and preliminary evaluation
… bearing the radiolabel often wash out of the cells decreasing … C, with surface-bound and
internalized activity determined … -2Rs15d, the differences between the two radioconjugates were …
internalized activity determined … -2Rs15d, the differences between the two radioconjugates were …
Targeted imaging of the atypical chemokine receptor 3 (ACKR3/CXCR7) in human cancer xenografts
… Here we report the evaluation of a radiolabeled ACKR3-targeted monoclonal antibody (…
(containing cell surface–bound 89 Zr-ACKR3-mAb) and cell pellets (containing internalized 89 Zr…
(containing cell surface–bound 89 Zr-ACKR3-mAb) and cell pellets (containing internalized 89 Zr…