Sticky patches on lipid nanoparticles enable the selective targeting and killing of untargetable cancer cells

M Sempkowski, C Zhu, MZ Menzenski, IG Kevrekidis… - Langmuir, 2016 - ACS Publications
… The 111 In-radiolabeled Trastuzumab was used to evaluate … internalized vesicles vs the sum
of surface-bound vesicles in … t test was used to calculate significant differences in behavior (…

Synthesis and in vitro and in vivo evaluation of urea-based PSMA inhibitors with increased lipophilicity

M Wirtz, A Schmidt, M Schottelius, S Robu, T Günther… - EJNMMI research, 2018 - Springer
surface-bound zinc metalloprotease prostate-specific … on the cell binding and internalization
of radiolabeled 10 and … To compensate for differences in cell count and viability, the external …

[PDF][PDF] HaloTag pseudotyped lentivirus: Quantifying uptake and internalisation in vitro using a fluorescent click sensor

JY Kuah - 2022 - scholar.archive.org
… to distinguish between surface bound and internalised materials and are … limits the use of
phenotyping antibodies in mixed cell … enzyme and followed by a gel extraction and purification …

Imaging c-Met expression using 18F-labeled binding peptide in human cancer xenografts

W Li, H Zheng, J Xu, S Cao, X Xu, P Xiao - PloS one, 2018 - journals.plos.org
… especially when the tracer is internalized inside the cells. … , pH = 2.8) to remove surface bound
radioactive ligand. Thereafter, the … whether it can differentiate between high and low c-Met-…

B cells rapidly target antigen and surface-derived MHCII into peripheral degradative compartments

S Hernández-Pérez, M Vainio… - Journal of Cell …, 2020 - journals.biologists.com
… high-affinity antibody responses, B cells internalise specific … To distinguish the internalised
antigen from the antigen still … We could, at least partially, overcome this limitation by …

Altered blood-brain barrier transport of nanotherapeutics in lysosomal storage diseases

M Solomon, M Loeck, M Silva-Abreu, R Moscoso… - Journal of Controlled …, 2022 - Elsevier
… removed by washing cells and surface bound NCs were … and we would observe no difference
between NCs targeted to … transferrin was simultaneously internalized into the cells, thus …

Transferrin-modified chitosan nanoparticles for targeted nose-to-brain delivery of proteins

B Gabold, F Adams, S Brameyer, K Jung… - Drug Delivery and …, 2023 - Springer
… , this cell line was used in this work to assess the differences … CS NPs with a surface bound
targeting ligand that can easily … NPs were specifically internalized by cells expressing TfR via …

Development and Evaluation of an 18F-Radiolabeled Monocyclam Derivative for Imaging CXCR4 Expression

D Brickute, M Braga, MA Kaliszczak… - Molecular …, 2019 - ACS Publications
… After incubation, surface-bound radioactivity was removed by … To obtain the internalized
fraction, the cells were lysed with … The difference in the tracer uptake between cell lines was …

Labeling single domain antibody fragments with 18F using a novel residualizing prosthetic agent—N-succinimidyl 3-(1-(2-(2-(2-(2-[18F] fluoroethoxy) ethoxy) ethoxy) …

Z Zhou, D McDougald, R Meshaw… - Nuclear medicine and …, 2021 - Elsevier
… 4 h, cell culture supernatants were removed, surface-bound activity was stripped from the …
to 5F7, which does internalize extensively. While this difference may be a factor influencing …

Red blood cell membrane bioengineered Zr-89 labelled hollow mesoporous silica nanosphere for overcoming phagocytosis

JY Lee, CK Vyas, GG Kim, PS Choi, MG Hur… - Scientific reports, 2019 - nature.com
… was used to harvest NPs from the internalized cancer cells. … citrate for 5 min to remove
surface bound Rm- 89 Zr-HMSNs. … CT-26 bearing mice were used to identify pharmacokinetic …