[HTML][HTML] Transferrin-modified chitosan nanoparticles for targeted nose-to-brain delivery of proteins

B Gabold, F Adams, S Brameyer, K Jung… - Drug Delivery and …, 2023 - Springer
… , this cell line was used in this work to assess the differences … CS NPs with a surface bound
targeting ligand that can easily … NPs were specifically internalized by cells expressing TfR via …

[HTML][HTML] Red blood cell membrane bioengineered Zr-89 labelled hollow mesoporous silica nanosphere for overcoming phagocytosis

JY Lee, CK Vyas, GG Kim, PS Choi, MG Hur… - Scientific reports, 2019 - nature.com
… was used to harvest NPs from the internalized cancer cells. … citrate for 5 min to remove
surface bound Rm- 89 Zr-HMSNs. … CT-26 bearing mice were used to identify pharmacokinetic …

[HTML][HTML] Aptamer cell-based selection: overview and advances

S Catuogno, CL Esposito - Biomedicines, 2017 - mdpi.com
… to identify multiple aptamers able to recognize specific cell phenotypes and discover new …
step to remove cell surface bound aptamers and recover only the internalized sequences. The …

Development and Evaluation of an 18F-Radiolabeled Monocyclam Derivative for Imaging CXCR4 Expression

D Brickute, M Braga, MA Kaliszczak… - Molecular …, 2019 - ACS Publications
… After incubation, surface-bound radioactivity was removed by … To obtain the internalized
fraction, the cells were lysed with … The difference in the tracer uptake between cell lines was …

Recent developments in cancer therapy and diagnosis

E Atlihan-Gundogdu, D Ilem-Ozdemir, M Ekinci… - Journal of …, 2020 - Springer
… , radiolabeled vasoactive intestinal peptides are used to … targeting and internalization. They
change their structures to … (CTLs) can recognize and kill tumor cells expressing HER2. While …

[HTML][HTML] Radiolabeled gold nanoseeds decorated with substance P peptides: synthesis, characterization and in vitro evaluation in glioblastoma cellular models

F Silva, A D'Onofrio, C Mendes, C Pinto… - International Journal of …, 2022 - mdpi.com
lower cellular internalization with a maximum internalization … Remarkable differences were
observed for the radiobiological … to the cellsurface bound radioactivity was collected. The …

… scFv-Cκ-scFv fusion protein and cotinine-duocarmycin can form antibody-drug conjugate-like complexes that exert cytotoxicity against mPDGFRβ expressing cells

S Kim, H Kim, DH Jo, JH Kim, SR Kim, D Kang… - Methods, 2019 - Elsevier
antibody internalization include using radiolabeled … differentiation of internalized and
surface-bound antibodies. … Interestingly, we observed that there is a little difference between the …

Synthesis and evaluation of new bifunctional chelators with Phosphonic acid arms for Gallium-68 based PET imaging in melanoma

Y Gai, L Sun, X Lan, D Zeng, G Xiang… - Bioconjugate …, 2018 - ACS Publications
… rapid internalization and high retention in B16F10 cells. … ± 1.0, p < 0.05), while the differences
of tumor uptake values of two … After removal of the surface-bound fraction, cell pellets were …

[HTML][HTML] The solute carrier SLC7A1 may act as a protein transporter at the blood-brain barrier

M Kurtyka, F Wessely, S Bau, E Ifie, L He… - … Journal of Cell Biology, 2024 - Elsevier
… that SLC7A1 internalised a SLC7A1-specific antibody in … The aim of our study was to identify
and validate novel candidate … and PBS pH 2 to dissociate surface-bound antibodies. Next, …

[HTML][HTML] Imaging EGFR and HER3 through 89Zr-labeled MEHD7945A (Duligotuzumab)

BN McKnight, ANW Kuda-Wedagedara, KK Sevak… - Scientific reports, 2018 - nature.com
… a decrease in internalization at 4 C (right) in all cell lines. (A) … performed on separate groups
of AsPC-1 cells exposed for 48 … Surface-bound activity was removed by washing the cells in …