… AD is a progressive disease with a long duration, and the pathogenesis is very complicated.
Here, we found that alpha-lipoic acid (LA), an endogenous, naturally synthesized compound…

… the neuroprotective … lipoic acid (α-LA) is a naturally occurring agent in food with
antioxidizing, anti-apoptotic, metal chelating, glioprotective, carbonyl scavenging, and anti-inflammatory …

… Alpha lipoic acid binds these metals to constitute stable complexes. Furthermore, alpha lipoic
acid … These results confirmed the neuroprotective effect of LA and provided evidence of its …

… short half-life characteristics are widely known problems about α-LA. However, α-LA presents
a neuroprotective and anti-inflammatory molecule profile with the ability to revert cellular …

… with Alzheimer’s disease (AD). BV2 cells were divided into control, LA, Aβ 25–35 , and LA …
anti-inflammatory and antioxidant substances may offer a promising approach to the treatment …

… , antioxidant, neuroprotective, and anti-inflammatory activities, and consequently act as …
–lipoic acid conjugates were synthesized as multifunctional anti-Alzheimer agents. The …

… Moreover, coumarin-3-carboxamides bearing LA have shown acceptable anti-inflammatory …
-lipoic acid conjugates 4–30, and evaluation of their antioxidant potential for neuroprotection …

… lipoic acid were obtained in order to combine in a single molecule the antioxidant and NRF2
induction properties of lipoic acid and the neuroprotective … and anti-inflammatory activity [11]…

… , ALA as a supplement was effective in the prevention of Alzheimer disease progression. For
… The anti-inflammatory effect of ALA is related to the inhibition of nuclear factor-κB (NF-κB), a …

… to their neuroprotective effect, they are known for their antioxidant, anti-inflammatory and …
are discussed: firstly, kynurenic acid, the main neuroprotective agent formed via the kynurenine …