… with different doses of lipopeptide (4.2, 1.5, and 0.5 mg per mouse). Animals body weight was
… In our study we demonstrated that for efficient siRNA delivery the optimal P:N ratio is 1:128 …

… siRNA target site in mouse and nonhuman primate, the efficacy of the Tie2 siRNA formulated
in 7C1 nanoparticles was first analyzed in a dose-response study in mice (fig. S1A). The …

… In nonhuman primates, high levels of knockdown of the … lipopeptides, which were shown
to be potent and selective … Additionally, cKK-E12 demonstrated potent selectivity toward liver …

… in efficient drug delivery, eg lipopeptide NPs are among the most potent NPs for the transfer
of selective siRNA delivery in non-human primates and rodents. siRNA therapeutic is used …

… been developed for siRNA delivery, few have been developed for mRNA delivery. … Lipopeptide
nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates …

… L101 was rapidly metabolized in the liver and was well tolerated when we delivered siRNA
doses of up to 16 mg/kg in rats. Moreover, we for the first time studied the metabolism of …

… nanoparticle (RBP131) and a state-of-the-art lyophilization technology were developed in
this study, enabling to deliver siRNA … complicated safety evaluations in mice and rats. First, a …

Here in this brief review, we have given brief basic information, discussed challenges of
siRNA delivery and important strategies along with representative compilation of some recent …

… The chemical structure of polymers as well as the selection of … a formulation can influence
nanoparticle potency, stability and … nanoparticle dose threshold has been discovered in mice: …

… class of lipopeptides (LP). In particular, we investigated the mechanism of binding of siRNA
with … 16 in HeLa cells, rodents, and nonhuman primates, characterized by different functional …