[HTML][HTML] Double Positive CD4+CD8+ (DP) T-Cells Display Distinct Exhaustion Phenotype in Chronic Hepatitis C

AM Kochanowicz, S Osuch, H Berak, A Kumorek… - Cells, 2023 - mdpi.com
infiltrate a site of chronic infection or tumor lesion [19,28]. For example, higher frequencies of
DP T-cells are found in liver … of circulating T helper and cytotoxic T-cells producing IFN-γ, IL-…

B and T cells:(Still) the dominant orchestrators in autoimmune hepatitis

MS Longhi, L Zhang, G Mieli-Vergani, D Vergani - Autoimmunity Reviews, 2024 - Elsevier
… of B and T lymphocyte subsets in the pathogenesis of AIH liver … Increased proportions of
circulating Th22 cells have been … the immunodominant HLA-A2 restricted CYP2D6 CD8 T cell

IL-2high tissue-resident T cells in the human liver: Sentinels for hepatotropic infection

LJ Pallett, J Davies, EJ Colbeck, F Robertson… - Journal of Experimental …, 2017 - rupress.org
… not the circulating memory CD8 T cell pool expressing liver-… Participants with chronic HBV
infection were anti–hepatitis C … peptide pools spanning the immunodominant proteins of CEF…

[PDF][PDF] Analysis of invariant natural killer T cells in health and disease: lessons from acute hepatitis C virus infection

C Menne - 2022 - docserv.uni-duesseldorf.de
… and the absence of detectable T cell activity in the liver shortly after infection. The humoral
… -CD28/49d and a pool of 22 immunodominant CMV peptides (table 2) that were restricted to …

Antibodies against immune checkpoint molecules restore functions of tumor-infiltrating T cells in hepatocellular carcinomas

G Zhou, D Sprengers, PPC Boor, M Doukas, H Schutz… - Gastroenterology, 2017 - Elsevier
… -infiltrating lymphocytes (TIL) and intra-hepatic lymphocytes. … patients with HCC with HBV
or hepatitis C virus (HCV) … observed that circulating TAA-specific CD8 + T cells express …

CD8+ T Cell Dysfunction in Chronic HCV Infection and its Association with Liver Fibrosis

F Deonarine - 2018 - ruor.uottawa.ca
hepatitis C virus (HCV) can cause liver damage known as fibrosis, which often leads to liver
… The impairment of circulating, bulk (non-specific and specific) CD8+ T cells within HCV-…

[HTML][HTML] … cell death-1 and T-cell immunoglobulin and mucin domain-containing protein 3 and plasma IL-10 levels after successful treatment of chronic hepatitis C

S Osuch, T Laskus, H Berak, K Perlejewski… - Scientific reports, 2020 - nature.com
Hepatitis C virus (HCV) infection is a common etiologic factor of chronic hepatitis, liver
HLA-A*02-restricted HCV NS3 1406 immunodominant epitope KLSGLGLNAV (corresponding to …

T-cell exhaustion and residency dynamics inform clinical outcomes in hepatocellular carcinoma

…, C Tauber, P Otto-Mora, T Ohtani, T Nilsson… - Journal of …, 2022 - Elsevier
… of exhausted and liver-resident T cells remain unclear. We … , such as accumulation of
recirculating T cells, might be better … B virus infection; cHCV, chronic hepatitis C virus infection; …

[PDF][PDF] Evolution of adaptive immune response from acute to chronic phase of hepatitis C virus infection

M Rasoli Pirozyan - 2018 - unsworks.unsw.edu.au
T cell was not associated with clearance. Immuno-phenotyping of liver showed that, liver was
enriched with T cells … examined, including on HCV-specific CD8+ T cells in the circulation. …

Regulatory T-cells promote hepatitis B virus infection and hepatocellular carcinoma progression

W Li, J Han, H Wu - Chronic diseases and translational medicine, 2016 - mednexus.org
chronic HBV infection, inflammatory liver damage is typically not the result of elevated numbers
of infiltrating CD8 + T-lymphocytes… The prevalence of circulating Tregs in the later stages …