Long-term survival after transformation of an adrenocorticotropic hormone–secreting pituitary macroadenoma to a silent corticotroph pituitary carcinoma

LE Rotman, TB Vaughan, JR Hackney, KO Riley - World Neurosurgery, 2019 - Elsevier
LE Rotman, TB Vaughan, JR Hackney, KO Riley
World Neurosurgery, 2019•Elsevier
Background Pituitary carcinomas are rare and aggressive neoplasms that despite current
treatment regimens continue to have a poor prognosis. Adrenocorticotrophic hormone
pituitary tumors have been shown to alter their clinical manifestations with conversion to
Cushing disease and silent types. Case Description The purpose of this paper is to present
the first documented case of an adrenocorticotrophic hormone–secreting pituitary adenoma
with Cushing disease that differentiated into a silent corticotroph pituitary carcinoma with …
Background
Pituitary carcinomas are rare and aggressive neoplasms that despite current treatment regimens continue to have a poor prognosis. Adrenocorticotrophic hormone pituitary tumors have been shown to alter their clinical manifestations with conversion to Cushing disease and silent types.
Case Description
The purpose of this paper is to present the first documented case of an adrenocorticotrophic hormone–secreting pituitary adenoma with Cushing disease that differentiated into a silent corticotroph pituitary carcinoma with metastases to distant sites in the central nervous system.
Conclusions
This patient was later treated with radiotherapy, temozolomide, and bevacizumab, with 8 years of progression-free survival.
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