… , resulted in severe motor neuron synaptic failure and death. This work demonstrates that a
miRNA … Loss of motoneuron-specific microRNA-218 causes systemic neuromuscular failure. …

… We recently demonstrated that microRNA-218 (miR-218) is … This precipitous decline may
suggest a failure of homeostatic … from surrounding glia that causes loss of homeostatic glial …

… Recent data have shown that microRNA-218 (miR-218) is … miR-218 is essential for perinatal
neuromuscular survival (1, 2), … , developmental loss of miR-218 causes motor neuron death, …

… [67, 68] and because its experimental deficiency causes systemic neuromuscular failure [68].
However, widespread neuronal death in the miR-218 mouse knockout embryos, hindered …

… atrophy (SMA), a leading genetic cause of infant death, is a … autosomal recessive
neuromuscular disorder caused by the … profiles of miRNAs may be caused by the failure of …

… When the action potential has reached the neuromuscular … These experiments showed that
in early development, loss of … Failure to clear Hoxb8 in a spatial and temporal manner leads …

… for a miRNA if it failed to be expressed at a … neuromuscular junctions and, ultimately, MN
degeneration (Amin et al., 2015). Although the loss of miR-218 developmentally causes MN …

10.7554/eLife.50848.001 Two crucial questions in neuroscience are how neurons establish
individual identity in the developing nervous system and why only specific neuron subtypes …

… Loss of motoneuron-specific microRNA-218 causes systemic … Loss of motoneuron-specific
microRNA-218 causes systemic neuromuscular failure. …

… Spinal muscular atrophy is caused by deletions or mutations in the SMN1 gene that result
in … Thus, SMA is an exemplar, selective motor neuron disorder that is caused by defects in …