… synthesis, which generates sufficiently long de novo microhomologies … levels of core C-NHEJ
components such as Artemis and DNA ligase IV were downregulated while DNA ligase III …

… DNA-dependent protein kinase (DNA-PKcs), DNA ligase IV (… Third, we identified two
conserved loops in the middle HEAT … The resolution of the linker loop was not good enough to …

… plus XRCC4:DNA ligase IV are necessary and sufficient to … Moreover, we would expect a
higher transition rate from low E … , we propose that up to three XLF dimers at the DNA ends may …

… end joining (NHEJ), which pairs DNA ends in a multiprotein … Ultimately, DNA ligase IV (LIG4),
which forms a constitutive … (80), supporting the idea that sufficient XLF tail length appears to …

… helicase and DNA polymerases λ and μ) and DNA ligase IV (… were found to be sufficient
for binding to DNA-PKcs through … The NHEJ specific DNA ligase LigIV contains an N-terminal …

… damaged DNA overhangs [42] but also bridges DNA ligases to … DNA Lig4 and to play an
essential role in facilitating NHEJ, … sufficient to complete the repair without the need of all NHEJ …

… /80 (KU), XRCC4, DNA Ligase 4 (LIG4), XLF, and DNAPKcs … bridge DNA ends via interactions
with other proteins in the C-NHEJ … To test this hypothesis, we examined three sites in the …

… biochemical NHEJ system to compare the joining of free DNA … DNA ligase IV were purified
from High Five cells using three-… DSB DNA ends at an already accessible site is not sufficient …

… kinase catalytic subunit (DNA-PKcs), XRCC4, DNA Ligase 4 (LIG4)… These core factors are
sufficient to recognize, align, and … -bp DNA duplex with a three-way junction comprising a 4-bp …

… directly ligatable by the DNA ligase 4 complex (with XRCC4 and … sufficiently far apart, any of
the three eukaryotic DNA ligases … permit adequate space for this complex to bind either DNA …