Plant PAXX has an XLF‐like function and stimulates DNA end joining by the Ku‐DNA ligase IV/XRCC4 complex

H Khan, T Ochi - The Plant Journal, 2023 - Wiley Online Library
… The minimal core NHEJ proteins, namely Ku70, Ku80, DNA ligase IV … are likely to carry out
three NHEJ steps similar to those in … function, it is unsurprising that one of them is enough for …

PARP1 links CHD2-mediated chromatin expansion and H3. 3 deposition to DNA repair by non-homologous end-joining

MS Luijsterburg, I de Krijger, WW Wiegant, RG Shah… - Molecular cell, 2016 - cell.com
… recruitment to sites of DNA damage, was sufficient to bind PARP1 (… fibroblasts using three
independent siRNAs reduced the … DNA ligase IV-dependent NHEJ of deprotected mammalian …

Allogeneic hematopoietic stem cell transplantation in two brothers with DNA ligase IV deficiency: a case report and review of the literature

S Schober, K Schilbach, M Doering… - BMC pediatrics, 2019 - Springer
… double-strand breaks by the non-homologous end-joining (NHEJ) … Three children were
born to Caucasian, non-… Conspicuously, the boy did not show adequate antibody titers after …

Xrcc5/Ku80 is required for the repair of DNA damage in fully grown meiotically arrested mammalian oocytes

X Cai, JM Stringer, N Zerafa, J Carroll, KJ Hutt - Cell Death & Disease, 2023 - nature.com
… These proteins function in three general stages: (1) Ku70/… Loss of some NHEJ factors, like
XRCC4 and DNA ligase IV, … of an effective DNA damage response sufficient to induce a cell …

Hypomorphic mutations in human DNA ligase IV lead to compromised DNA binding efficiency, hydrophobicity and thermal stability

ER Maddi, SC Raghavan… - … Engineering, Design and …, 2021 - academic.oup.com
… LigIV gene polymorphisms mainly hamper the efficient NHEJ … 5), we find that DBDWt and
all the three hypomorphic mutants … be sufficient to disturb the critical interactions necessary for …

Analysis of the distribution and evolution of the ATP‐dependent DNA ligases of bacteria delineates a distinct phylogenetic group 'L ig E'

A Williamson, E Hjerde, T Kahlke - Molecular microbiology, 2016 - Wiley Online Library
… B and the NHEJ ligases, Lig C, Lig D1, D2 and D3; the second comprising only Lig E (Fig. 4).
… from related bacteria, the latter is sufficiently divergent from other Lig E sequences to form a …

DNA Ligase 1 is an essential mediator of sister chromatid telomere fusions in G2 cell cycle phase

K Liddiard, B Ruis, Y Kan, K Cleal… - Nucleic acids …, 2019 - academic.oup.com
… fundamental contribution of DNA ligase 4-dependent classical … and the express involvement
of NHEJ components in their … −/flox:CreERt2 cells sufficient for all three ligases revealed no …

[HTML][HTML] Mitochondrial DNA damage induced autophagy, cell death, and disease

B Van Houten, SE Hunter, JN Meyer - Frontiers in bioscience …, 2016 - ncbi.nlm.nih.gov
… subunit of Complex III, three subunits of Complex IV and two … of any DNA ligase activity
in mitochondria was sufficient to … The irradiation resulted in lower levels of mtDNA (ie, lower

Rad51 and RecA juxtapose dsDNA ends ready for DNA ligase-catalyzed end-joining under recombinase-suppressive conditions

N Konomura, N Arai, T Shinohara… - Nucleic Acids …, 2016 - academic.oup.com
… The Ku-heterodimer and DNA ligase IV (Lig4) are the major … To find new functions that can
explain their possible roles in NHEJ (… (18) indicated that Ku is not sufficient, and Rad51 is also …

YALIcloneNHEJ: An Efficient Modular Cloning Toolkit for NHEJ Integration of Multigene Pathway and Terpenoid Production in Yarrowia lipolytica

YW Li, CL Yang, Q Shen, QQ Peng, Q Guo… - … in Bioengineering and …, 2022 - frontiersin.org
… , including the amounts of ligase and the reaction cycles, the assembly efficiency of 4, 7, and
10 … all three enzymes (Figure 2B). Taking into account the lower price of T4 DNA ligase from …