… DNA ligase IV. Furthermore, they found that the expression of the target gene diminished in
the cells undergoing NHEJ … However, the expression of dCas9-CtIP is not sufficient by itself …

… Ligase 4 (LIG4) is responsible for nonhomologous end-joining … strand break repair through
the alternative-NHEJ pathway (12, 13)… In both patients, a transcobalamin II deficiency was first …

… , encoded in the LIG4 gene, is a component of the NHEJ … The residual DNA ligase IV activity
is probably sufficient for V(… of three unrelated patients with different phenotypes of ligase …

… Assuming that transient expression might not be sufficient to … We have observed high NHEJ
efficiency in all three cases. … –4 base in the noncomplementary strand since the base at –4 …

… , including the amounts of ligase and the reaction cycles, the assembly efficiency of 4, 7, and
10 … all three enzymes (Figure 2B). Taking into account the lower price of T4 DNA ligase from …

… NHEJ factors DNA-PK CS and Ligase IV, but clinical applicability for the great majority of them
is hampered by poor pharmacodynamics, low … , our compound exhibits adequate solubility …

… patients with surgery and with adequate specimen of tumor tissue; … 4A,B, the protein level of
DNA-PKcs and LIG4 were … affects NHEJ repair activity by regulating expression level of DNA-…

… of the NHEJ system, including DNA Ligase IV, DNA-PKcs, … across three core components
of NHEJ, Ku70/80, DNA-PKcs … variants to nucleic acids due to a need for more sufficient data…

… starkeyi have not been sufficiently developed. In this study, … of broken DNA strands, which
requires for DNA ligase IV for … and/or ligase IV of the competitive NHEJ pathway, we performed …

… 10 4 cells) in a well of a 96-well plate to monitor the NHEJ activity … the resulting three alleles
(wild-type, HDR, and NHEJ) were … did not generate sufficient interaction with DNA to induce …