Macrolide hybrid compounds: drug discovery opportunities in anti-infective and anti-inflammatory area
H Cipcic Paljetak, L Tomaskovic… - Current topics in …, 2017 - ingentaconnect.com
Macrolides, polyketide natural products, and their 15-membered semi-synthetic derivatives
are composed of substituted macrocyclic lactone ring and used primarily as potent
antibiotics. Recently their usefulness was extended to antimalarial and anti-inflammatory
area. Hybrid macrolides presented in this article are the next generation semi-synthetic
compounds that combine pharmacophores from antibacterial, antimalarial and anti-
inflammatory area with 14-and 15-membered azalide scaffolds. Antibacterial azalide hybrids …
are composed of substituted macrocyclic lactone ring and used primarily as potent
antibiotics. Recently their usefulness was extended to antimalarial and anti-inflammatory
area. Hybrid macrolides presented in this article are the next generation semi-synthetic
compounds that combine pharmacophores from antibacterial, antimalarial and anti-
inflammatory area with 14-and 15-membered azalide scaffolds. Antibacterial azalide hybrids …
[PDF][PDF] Macrolide Hybrid Compounds: Drug Discovery Opportunities in Anti-Infective and Anti-Inflammatory Area
HČ Paljetaka, L Tomaškovićb… - Current Topics in …, 2017 - researchgate.net
Macrolides, polyketide natural products, and their 15-membered semi-synthetic derivatives
are composed of substituted macrocyclic lactone ring and used primarily as potent
antibiotics. Recently their usefulness was extended to antimalarial and anti-inflammatory
area. Hybrid macrolides presented in this article are the next generation semi-synthetic
compounds that combine pharmacophores from antibacterial, antimalarial and anti-
inflammatory area with 14-and 15-membered azalide scaffolds. Antibacterial azalide hybrids …
are composed of substituted macrocyclic lactone ring and used primarily as potent
antibiotics. Recently their usefulness was extended to antimalarial and anti-inflammatory
area. Hybrid macrolides presented in this article are the next generation semi-synthetic
compounds that combine pharmacophores from antibacterial, antimalarial and anti-
inflammatory area with 14-and 15-membered azalide scaffolds. Antibacterial azalide hybrids …
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