[PDF][PDF] CD8+ T cell priming in established chronic viral infection preferentially directs differentiation of memory-like cells for sustained immunity

LM Snell, BL MacLeod, JC Law, I Osokine… - Immunity, 2018 - cell.com
… CD4+ T cell help for its functional generation. Chronic viral … The role of priming DC was
further corroborated using infection … the memory CD8+ T cell pathway was enriched in Tlp cells (…

The architectural design of CD8+ T cell responses in acute and chronic infection: Parallel structures with divergent fates

HK Chung, B McDonald, SM Kaech - Journal of Experimental Medicine, 2021 - rupress.org
… goal of generating large numbers of effector T cells to help … Comparative analyses of the
effector and memory CD8 + T cell … As the determination of cell subsets or states using single-cell

Memory CD 8 T cell inflation vs tissue‐resident memory T cells: Same patrollers, same controllers?

SPM Welten, I Sandu, NS Baumann… - Immunological …, 2018 - Wiley Online Library
memory CD8 T cell precursors develop into long-lived cells … preventing the generation of
long-lived memory cells,166 is … in the same experiment using the same technology for RNA …

Local antigen in nonlymphoid tissue promotes resident memory CD8+ T cell formation during viral infection

TN Khan, JL Mooster, AM Kilgore, JF Osborn… - Journal of Experimental …, 2016 - rupress.org
… In addition to the generation of circulating memory CD8 + T cellCD8 + T cells were activated
after infection of the skin using ex … Between days 7 and 15 after infection, the percentage of …

[HTML][HTML] Exposure to SARS-CoV-2 generates T-cell memory in the absence of a detectable viral infection

Z Wang, X Yang, J Zhong, Y Zhou, Z Tang… - Nature …, 2021 - nature.com
… of IFNγ + T cells ± SEM; Percentage shown on top of the … may have led to the generation
of T cell immunity even in the … contacts and 30 healthy donors by using an overnight “ex vivo” …

Cytokine-mediated regulation of CD8 T-cell responses during acute and chronic viral infection

M Hashimoto, SJ Im, K Araki… - Cold Spring Harbor …, 2019 - cshperspectives.cshlp.org
using IL-2-deficient mice showed that antiviral CD8 T-cellCD8 T cells did not show any
impairment for the generationMemory CD8 T cells induced after a primary acute infection

CD4+ T help promotes influenza virus-specific CD8+ T cell memory by limiting metabolic dysfunction

JG Cullen, HA McQuilten, KM Quinn… - Proceedings of the …, 2019 - National Acad Sciences
… to establishing optimal CD8 + T cell memory generation and … priming ensures that memory
CD8 + T cells are programmed … assessed oxygen consumption rates (OCR) using a Seahorse …

Resident memory CD8+ T cells in the upper respiratory tract prevent pulmonary influenza virus infection

A Pizzolla, THO Nguyen, JM Smith, AG Brooks… - Science …, 2017 - science.org
… 2 days later and analyzed on day 20 pi The percentage (H) … 3B), mice rechallenged 120
days after the primary infectioninfection and assessed nasal Trm cells development using a …

The impact of TCR signal strength on resident memory T cell formation during influenza virus infection

JK Fiege, IA Stone, EJ Fay, MW Markman… - The Journal of …, 2019 - journals.aai.org
generation and maintenance of lung T RM after IAV infection. … demonstrated to shape memory
CD8 + T cell differentiation. … Using a reductionist approach, we were able to demonstrate …

[HTML][HTML] The precursors of CD8+ tissue resident memory T cells: from lymphoid organs to infected tissues

L Kok, D Masopust, TN Schumacher - Nature Reviews Immunology, 2022 - nature.com
… You are using a browser version with limited support for CSS. To … T RM cell lineage, resulting
in the generation of a pool of TT cells, at the level of both naive and early effector T cells, to …