Memory CD8+ T cell responses to cancer

J Han, N Khatwani, TG Searles, MJ Turk… - Seminars in …, 2020 - Elsevier
… and, unlike immunity to acute infections, curative immunity to … the possibility of generating
functional T-cell memory against cancer… were found using CMV-pp65 specific T cells taken from …

Cutting edge: the aging immune system reveals the biological impact of direct antigen presentation on CD8 T cell responses

JL Uhrlaub, MJ Smithey… - The Journal of …, 2017 - journals.aai.org
Using a double-deletion mutant (∆12∆203) of CPXV, we … pressure that led to the generation
of CPXV12 and CPXV203 by … strongly protective memory CD8 T cell responses against an …

Epigenetic signature of PD-1+ TCF1+ CD8 T cells that act as resource cells during chronic viral infection and respond to PD-1 blockade

RR Jadhav, SJ Im, B Hu, M Hashimoto… - Proceedings of the …, 2019 - National Acad Sciences
… for the generation of this stem-like CD8 T cell population … profiles of sorted CD8 T cell subsets
were examined using ATAC-seq … CD8 T cell subsets with effector and memory CD8 T cells

Epigenetic scarring of exhausted T cells hinders memory differentiation upon eliminating chronic antigenic stimulation

MS Abdel-Hakeem, S Manne, JC Beltra… - Nature …, 2021 - nature.com
Memory CD8 T cells (T MEM ) persist long-term, can self-… Here, we addressed these
questions using the mouse model … of generating appropriately differentiated secondary T EFF . …

A Higher Activation Threshold of Memory CD8+ T Cells Has a Fitness Cost That Is Modified by TCR Affinity during Tuberculosis

SM Carpenter, C Nunes-Alves, MG Booty… - PLoS …, 2016 - journals.plos.org
… 4 antigen during infection, we observe memory-derived T cells to … We propose that generating
memory T cells with high … By directly comparing naïve and memory CD8 + T cells using our …

KLRG1+ effector CD8+ T cells lose KLRG1, differentiate into all memory T cell lineages, and convey enhanced protective immunity

…, T Inoue, Y Kluger, SM Kaech, T Kurosaki, T Okada… - Immunity, 2018 - cell.com
Using genetic fate mapping analysis of highly cytotoxic … and malignant diseases, and
memory CD8 + T cell … We further showed that such plasticity was a driving force in generating

CD8+ Resident Memory T Cells and Viral Infection

X Wu, P Wu, Y Shen, X Jiang, F Xu - Frontiers in immunology, 2018 - frontiersin.org
… However, in acute VACV skin infection mouse model we did … of functional CD8 + Trm cells
and amplifies their generation. … therapeutically manipulating CD8 + Trm cell development, …

Type I interferon suppresses virus-specific B cell responses by modulating CD8+ T cell differentiation

EA Moseman, T Wu, JC de la Torre… - Science …, 2016 - science.org
… Between days 3 and 4 after infection, we observed that P14 T cellsUsing TPM, we examined
interactions between splenic … By generating GCaMP6s transgenic mice, we studied cell-cell

Differential requirements for Tcf1 long isoforms in CD8+ and CD4+ T cell responses to acute viral infection

JA Gullicksrud, F Li, S Xing, Z Zeng, W Peng… - The Journal of …, 2017 - journals.aai.org
… maturation of central memory CD8 + T cells and their optimal … ≥2-fold expression changes
and a false discovery rate q … Using a new mouse model in which generation of transcripts …

Inhibitory signaling sustains a distinct early memory CD8+ T cell precursor that is resistant to DNA damage

JB Johnnidis, Y Muroyama, SF Ngiow, Z Chen… - Science …, 2021 - science.org
Generation of memory T cells is an essential part of protective immunity against pathogens
after initial infection … improve CD8 + T cell memory after vaccination through manipulating the …