… Thus, effective therapeutic approaches are of high clinical … activation via several cytokines
(for example, JAK3 is activated … 2 and T H 9 cytokine levels in this disease, these observations …

… cytokines may be useful biomarkers for health and disease and act as diagnostic, prognostic
and therapeutic … Cytokines as therapeutic targets IL-1 and IL-2 showed potential as natural …

… of the cytokine may complicate design of effective therapy. … cytokines that also includes
several other cytokines that have been implicated in the pathogenesis of cardiovascular diseases…

… IL-17A and IL-7F are therefore good therapeutic targets in severe neutrophilic asthma and
in COPD, particularly as patients with increased T H 17 cells and IL-17 are steroid resistant …

… However, TNF-α antagonists such as etanercept, infliximab, or adalimumab proved to be
a highly effective treatment for auto-inflammatory diseases like psoriasis, Crohn’s …

… Disease course is often complicated by the development of … none of the available cytokine
blockers is effective in all IBD … of patients could benefit from specific anti-cytokine therapies. …

… mediators (such as cytokines, chemokines, growth factors) as … therapies, particular where
corticosteroids are less effective, … There is a need to develop more effective therapies for these …

… disease pathogenesis and amplification. Therefore, cytokine neutralization is a useful therapeutic
… pro-inflammatory cytokines and, as such, interesting therapeutic targets for controlling …

… beneficial effects of antioxidant and nutraceutical therapies. In addition, we highlight the
growth of biologics and their targets … genes coding for inflammatory cytokines. Polymorphism in …

… arthritis, giant cell arteritis and Castleman disease, with drugs that target IL-6 (refs 5,10,11,12
)… -6 family cytokines and their clinical potential as therapeutic targets or disease modifiers in …