Quantitative and qualitative assessment of aortic structure and function, and elastic fiber ultrastructure in the mouse model of Marfan syndrome

ZJ Cui - 2017 - open.library.ubc.ca
wave velocity (PWV) was significantly elevated in MFS mice … that is critically involved in
vasodilation and has been used as … month old MFS mice, fiber lengths are significantly decreased

Calcium promotes vascular smooth muscle cell phenotypic switching in Marfan syndrome

Y Yang, E Xie, Y Liu, Z Peng, C Yu, K Hua… - … and Biophysical Research …, 2023 - Elsevier
… Syyong et al. found that the frequency of calcium waves is reduced in the second-order
branches of the mesenteric artery of MFS mice (Fbn1 C1039G/+ ) at 24 weeks of age [26]. A …

[HTML][HTML] Structure-related blockage of calcium channels by vasodilator alkamides in mice mesenteric artery

DCG Garcia, AC Pereira, SJC Gutierrez… - Vascular …, 2016 - Elsevier
… of the Ca 2 + influx for the contraction of resistance arteries [… , the alkamides significantly
inhibited its vasoconstrictor effect (Fig. 5)… that they reduce the increase in the intracellular Ca 2 + …

[HTML][HTML] Activation of Cav1. 2 and BKCa is involved in the downregulation of caffeine-induced contraction in mice mesenteric arteries

DCG Garcia, MJ Lopes, UC Mbiakop, VS Lemos… - Life sciences, 2019 - Elsevier
… 1.2 increased the TC while reduced the i Ca 2+ signal. Similar … of VSMCs contraction in
resistance arteries. The evidence of … when we compare Ca 2+ -sparks or Ca 2+ -waves [12]. In …

NADPH oxidase 4 attenuates cerebral artery changes during the progression of Marfan syndrome

Y Onetti, T Meirelles, AP Dantas… - American Journal …, 2016 - journals.physiology.org
… To our knowledge, only mesenteric resistance artery … in active relative to passive (0 Ca 2+
-KHS) conditions revealed … in MCA of Marfan mice, we generated a Marfan mice model, which …

Aortic stiffness in L-NAME treated C57Bl/6 mice displays a shift from early endothelial dysfunction to late-term vascular smooth muscle cell dysfunction

S De Moudt, JO Hendrickx, C Neutel… - Frontiers in …, 2022 - frontiersin.org
… control mice, indicating that L-NAME treatment increases the … In this context, insulin-induced
vasodilation may represent a … and resistance arteries in L-NAME induced cardiovascular …

Vascular smooth muscle cells in Marfan syndrome aneurysm: the broken bricks in the aortic wall

GL Perrucci, E Rurali, A Gowran, A Pini… - Cellular and Molecular …, 2017 - Springer
… Since Ca 2+ waves are tightly associated with vasoconstriction, it … Ca 2+ in second-order
mesenteric arteries from Fbn1 C1039G/+ mice revealed a decreased frequency of Ca 2+ waves

The onset of cardiovascular disease in mice: an image-based, computational-experimental approach

L Aslanidou - 2019 - infoscience.epfl.ch
… Rp is peripheral resistance (summed resistance of peripheral beds)… As we saw, in Marfan
syndrome the defective synthesis of … rat mesenteric arteries to measure their vasoconstriction or …

An iPSC-derived vascular model of Marfan syndrome identifies key mediators of smooth muscle cell death

A Granata, F Serrano, WG Bernard, M McNamara… - Nature …, 2017 - nature.com
… Similar contraction and Ca 2+ flux abnormalities were … of reducing TGF-β activity, losartan
was able to lower MMP … cells in small arteries of a mouse model of Marfan syndrome. Br. J. …

Intrinsic Mechanics of Human Stem Cell Derived Aortic Smooth Muscle Cells Support a Developmental Basis for Aneurysm Localization in Marfan Syndrome

RJ Wiener, H Orins, KD Costa - bioRxiv, 2023 - biorxiv.org
Marfan Syndrome Decreases Ca2+ Wave Frequency and Vasoconstriction in Murine Mesenteric
Resistance Arteries without Changing Underlying Mechanisms. JVR 48, 150–162 (2011…