Cerebrospinal fluid matrix metalloproteinase 9 levels, blood-brain barrier permeability, and treatment outcome in tuberculous meningitis

S Mailankody, GV Dangeti, R Soundravally… - PLoS …, 2017 - journals.plos.org
… Tuberculous meningitis is characterized by elevated levels of matrix metalloproteinase 9 (MMP9)
in the cerebrospinal fluid (CSF). However, it is unclear whether elevated MMP9 levels …

role of matrix metalloproteinase9 in progression of tuberculous meningitis: a pilot study in patients at different stages of the disease

S Majeed, P Singh, N Sharma, S Sharma - BMC Infectious diseases, 2016 - Springer
… and reverse zymography in cerebrospinal fluid and serum of tuberculous meningitis patients
at different stages of the disease. Further, role of MMP-9 as therapeutic target was studied …

Matrix metalloproteinases in pulmonary and central nervous system tuberculosis—a review

UK Rohlwink, NF Walker, AA Ordonez, YJ Li… - International journal of …, 2019 - mdpi.com
… The level and presence of specific MMPs and their inhibitors in the cerebrospinal fluid (CSF)
and blood of patients may therefore be markers of BBB compromise. However, human …

Matrix metalloproteinases contribute to the regulation of chemokine expression and pulmonary inflammation in Cryptococcus infection

O Supasorn, N Sringkarin, P Srimanote… - Clinical & …, 2016 - academic.oup.com
patients with cryptococcosis showed high levels of MMP-9 in the cerebrospinal fluid (CSF)
of patients … GM6001 could limit the growth of fungus but does not eradicate fungal burden. In …

Elevated matrix metalloproteinase concentrations offer novel insight into their role in pediatric tuberculous meningitis

YJ Li, KA Wilkinson, RJ Wilkinson… - Journal of the …, 2020 - academic.oup.com
… We collected lumbar and ventricular cerebrospinal fluid and serum from 40 children treated
… of matrix metalloproteinase 9 (MMP-9), MMP-2, tissue inhibitor of metalloproteinase 1 (TIMP-…

[PDF][PDF] A Comparative Study of Serum Matrix Metalloproteinase-9 in Tuberculous Meningitis With and Without Stroke

R Jhamb, AK Gauraw, R Kar, P Gogoi… - International Journal of …, 2019 - academia.edu
… Persistent increase of matrix metalloproteinases in cerebrospinal fluid of tuberculous …
Marked increase of matrix metalloproteinase 9 in cerebrospinal fluid of patients with fungal or …

Neutrophil-Mediated Immunopathology and Matrix Metalloproteinases in Central Nervous System–Tuberculosis

XY Poh, FK Loh, JS Friedland, CWM Ong - Frontiers in Immunology, 2022 - frontiersin.org
… (9). There is accumulating evidence that neutrophil-derived mediators including matrix
metalloproteinase-9 (MMP-9) … Patients with subacute meningitis, including fungal meningitis and …

The role of matrix metalloproteinase in inflammation with a focus on infectious diseases

HS Lee, WJ Kim - International Journal of Molecular Sciences, 2022 - mdpi.com
… as bacteria, viruses, protozoa, and fungi. Excessive activity of MMPs induced by infection …
-8 and MMP-9 are found in the cerebrospinal fluid of patients with bacterial meningitis [115]. …

[PDF][PDF] Expression of matrix metalloproteinase9 in mice with tuberculous meningitis and its significance

XP Li, GL Ding, JL Chen, CH Huang, CY Li… - Int J Clin Exp …, 2016 - e-century.us
… There was an increase in the number of OX-42-labeled … was found to be increased in patients
cerebrospinal fluid, while its … viruses and fungi, the expression of MMP-9 was significantly …

Harnessing the activity of the fungal metalloprotease, Mpr1, to promote crossing of nanocarriers through the blood–brain barrier

PA Aaron, A Gelli - ACS Infectious Diseases, 2019 - ACS Publications
… that a secreted fungal metalloprotease, Mpr1, that also confers crossing ability to yeast upon
… This study substantiates the notion that fungal mechanisms of BBB entry may be harnessed …