Development of a Radiopharmaceutical Carrier for PET Lung Perfusion Studies

S Shabnam - 2020 - theses.hal.science
… with gallium-68 eluate (68GaCl3). The presented radiopharmaceutical visualized the lungs
… generator for daily production of 68Ga and dose calibrator for dose measurements located …

68Ga PET ventilation and perfusion lung imaging—current status and future challenges

DL Bailey, EM Eslick, GP Schembri… - Seminars in nuclear …, 2016 - Elsevier
Gallium-68 ( 68 Ga) is a positron-emitting radionuclide … ]-transferrin to study the flux of
radiolabeled proteins across the … with measurements derived from PET images of pulmonary

Gallium-68 labelled radiopharmaceuticals for imaging inflammatory disorders

M Vorster - Seminars in Nuclear Medicine, 2023 - Elsevier
Gallium-68-based PET offers imaging possibilities for nearly … such as increases in vascular
permeability, changes in the … provides a measure of ROS activity in acutely injured lungs and …

[PDF][PDF] New approaches to radionuclide imaging of cancer with gallium-68

C Imberti - 2018 - kclpure.kcl.ac.uk
… competitive binding of 68Ga by transferrin or other proteins. … Emission Tomography (PET)
scans. Owing to its short half-life, … This is likely due to their increased capillary permeability and …

[HTML][HTML] Radiopharmaceutical labelling for lung ventilation/perfusion PET/CT imaging: a review of production and optimization processes for clinical use

F Blanc-Béguin, S Hennebicq, P Robin, R Tripier… - Pharmaceuticals, 2022 - mdpi.com
… However, carrier molecules are labelled with gallium-68 ( 68 Ga) … A total of 98% of activity
was measured in the lungs … binding affinity to the blood serum protein transferrin (log K1 = 20.3)…

Gallium Imaging of Infection and Inflammation

M Vorster, M Sathekge - Nuclear Medicine and Immunology, 2022 - Springer
transferrin, ferritin, and lactoferrin [7]. It stands to reason that … Vascular permeability increases
significantly to allow a … gallium imaging, especially gallium-68, as applied to PET imaging of …

Physiological Animal Imaging with 68Ga-Citrate

A Uğur, A Gültekin - Current radiopharmaceuticals, 2021 - ingentaconnect.com
… : Gallium-68 is an ideal research and hospital-based PET … , increased vascular permeability,
plasma transferrin binding and … 68Ga-citrate activity was measured in a Comecer VDC-606 …

Gallium: New developments and applications in radiopharmaceutics

PJ Blower, R Cusnir, A Darwesh, NJ Long… - Advances in Inorganic …, 2021 - Elsevier
… It is able to rapidly transchelate gallium bound to transferrin in … and gallium-68 (93%, 15 min,
RT, pH 4.5, [L] = 1 × 10 −4 M). … was designed as a gallium-68 labeled PET-PDT theranostic …

Gallium-68 PET: a powerful generator-based alternative to infection and inflammation imaging

M Vorster, A Maes, C van de Wiele… - Seminars in Nuclear …, 2016 - Elsevier
… vasodilation, binding to transferrin in plasma, and binding to lactoferrin and siderophores. …
targets for imaging: vasodilation, increased vascular permeability, infiltration of WBCs (mainly …

Nuclear Imaging of Inflammation

G Keeling, F Man - Imaging Inflammation, 2023 - Springer
… such as changes in vascular permeability, or much more targeted … A popular radiometal for
PET imaging is gallium-68. … with metal-binding proteins such as transferrin or ferritin, whereas …