Electrophysiological evidence for the existence of a rare population of C-fiber low threshold mechanoreceptive (C-LTM) neurons in glabrous skin of the rat hindpaw

L Djouhri - Neuroscience letters, 2016 - Elsevier
… of the skin is mediated by distinct classes of low-threshold … : (1) abolition of mechanical
allodynia associated with muscle … as it might seem because cutaneous unmyelinated C-afferent …

Low-frequency stimulation of silent nociceptors induces secondary mechanical hyperalgesia in human skin

K Sauerstein, J Liebelt, B Namer, R Schmidt… - Neuroscience, 2018 - Elsevier
… and touch-evoked allodynia in human skin. Punctate hyperalgesia … development of secondary
mechanical hyperalgesia and of … and even more for other low-threshold fibers, we cannot …

Low-threshold mechanoreceptors play a frequency-dependent dual role in subjective ratings of mechanical allodynia

LS Löken, EP Duff, I Tracey - Journal of Neurophysiology, 2017 - journals.physiology.org
… that the myelinated low-threshold mechanoreceptors (LTMs) … of Aβ-mediated dynamic
mechanical allodynia (DMA) presented a … Dynamic mechanical allodynia is an important feature of …

Evidence for sparse C-tactile afferent innervation of glabrous human hand skin

RH Watkins, M Dione, R Ackerley… - Journal of …, 2021 - journals.physiology.org
mechanoreceptive afferents in the glabrous skin of the … from the low-threshold C-fibers
described in the present study. … in glabrous hand skin and could mediate mechanical allodynia, …

Aδ-fiber low threshold mechanoreceptors innervating mammalian hairy skin: a review of their receptive, electrophysiological and cytochemical properties in relation to …

L Djouhri - Neuroscience & Biobehavioral Reviews, 2016 - Elsevier
… the mammalian hairy skin is mediated by morphologically and … In humans, microneurographic
recordings from the cutaneous … of primary afferent fibers between hairy and glabrous skin. …

Nav1.7 is required for normal C-low threshold mechanoreceptor function in humans and mice

SJ Middleton, I Perini, AC Themistocleous, GA Weir… - Brain, 2022 - academic.oup.com
… is mediated by the specialized afferents C-low threshold mechanoreceptors (C-LTMRs). …
of mechanosensitive units on glabrous skin with delayed responses to mechanical stimulation, …

[图书][B] Slow Touch and Fast Nociception: Exploration of the Interactions Between Noxious and Innocuous Mechanical Touch Sensation

A Marshall - 2019 - search.proquest.com
mechanical stimuli are encoded by cutaneous low threshold … -fibres, termed C-low threshold
mechanoreceptor (C-LTMR) … humans that pathways mediating ascending relay of noxious …

Is optogenetic activation of Vglut1-positive Aβ low-threshold mechanoreceptors sufficient to induce tactile allodynia in mice after nerve injury?

A Chamessian, M Matsuda, M Young… - Journal of …, 2019 - Soc Neuroscience
… Despite much study, it is still unknown which type of PSN mediates mechanical allodynia. …
dermis and formed characteristic cutaneous end organs. In the glabrous skin of the hindpaw, …

Microneurography as a tool to study the function of individual C-fiber afferents in humans: responses from nociceptors, thermoreceptors, and mechanoreceptors

R Ackerley, RH Watkins - Journal of neurophysiology, 2018 - journals.physiology.org
mediating temperature sensations in different human skin types, where there are no studies
from glabrous skin, and how cutaneous … the skin will generate percepts that are mediated by …

Getting in touch with mechanical pain mechanisms

RZ Hill, DM Bautista - Trends in Neurosciences, 2020 - cell.com
… perform a similar function in glabrous skin is unknown, as … , a subset of Aβ-low threshold
mechanoreceptor (LTMR) … This finding was surprising since Aβ LTMRs are thought to mediate