Hypoxia: a double-edged sword in cancer therapy

H Manoochehri Khoshinani, S Afshar… - Cancer …, 2016 - Taylor & Francis
… , hypoxia-activated prodrugs, hypoxia-specific gene therapy, and hypoxia-targeting fusion
Procaspase-3 can be used as a cytotoxic domain of fusion protein. For overcoming the …

A novel injectable BRET-based in vivo imaging probe for detecting the activity of hypoxia-inducible factor regulated by the ubiquitin-proteasome system

T Kuchimaru, T Suka, K Hirota, T Kadonosono… - Scientific reports, 2016 - nature.com
… more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime,
… Therefore, fusing the motifs to certain proteins can endow the fused proteins with the same …

[HTML][HTML] SPINK1 as a plasma marker for tumor hypoxia and a therapeutic target for radiosensitization

T Suwa, M Kobayashi, Y Shirai, JM Nam, Y Tabuchi… - JCI insight, 2021 - ncbi.nlm.nih.gov
… We investigated molecular mechanisms underlying the … Next, we addressed the molecular
mechanism by which … , which expresses a fusion protein of EGFP and 53 binding protein 1 (…

A Novel Hypoxia Imaging Endoscopy System

K Kaneko, H Yamaguchi, T Yano - Hypoxia and Human …, 2017 - books.google.com
… with neuropathy and acute toxicity on the CNS [33]. … over the years; meanwhile, hypoxia-specific
agents have also been … as HIF-1α, PTD-ODD fusion proteins are thought likely to be co-…

Application of HaloTag® Technology to in Vivo Molecular Imaging Using Protein Probes Labeled by Metallic Radionuclides

S Kimura, Y Kakishima, T Kuchimaru… - …, 2016 - jstage.jst.go.jp
protein and HaloTag ligands can be applied to a more sophisticated labeling method for
protein … For this purpose, we propose to use HaloTag-fusion proteins, which comprise targeting …

金属放射性核種で標識した蛋白質プローブを用いたHaloTag 技術のインビボ分子イメージングへの応用

木村禎亮, 柿島祐, 口丸高弘, 近藤科江, 吉本光喜… - …, 2016 - jlc.jst.go.jp
protein and HaloTag ligands can be applied to a more sophisticated labeling method for
protein … For this purpose, we propose to use HaloTag-fusion proteins, which comprise targeting …