… The biochemical regulation of TET protein-mediated 5mC oxidation is not completely
understood. When the enzymatic reaction proceeds beyond 5hmC, and 5fC or 5caC are formed, …

… functions of TET family … TET proteins can further iteratively oxidize 5-hmC to form 5-formylcytosine
(5-fC) and 5-carboxylcytosine (5-caC) [22, 23]. Over the past years, the function of TET …

… TET-mediated DNA oxidation plays prominent roles in a … mechanisms, mainly including
DNA methylation such as covalent modification of cytosine bases leading to 5-methylcytosine (…

… Tet) family, including Tet1, Tet2 and Tet3, are Fe(II)- and α-ketoglutarate (α-KG)-dependent
dioxygenases that oxidize 5-methylcytosine … of Tet regulation, indicating a potential role of the …

… alterations in the TET protein-mediated oxidation process. … alterations in the TET
protein-mediated oxidation process, which … in S1 was replaced by 5-methylcytosine m CGC GCG …

… oxidizing 5-methylcytosine (m 5 C) to 5-hydroxymethylcytosine (hm 5 C) and further oxidized
… have demonstrated that m 5 C and TET protein-mediated oxidation are also important in the …

… of 5-methylcytosine (5mC) is actively reversed to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine
(5fC) and 5-carboxylcytosine (5caC) through TET dioxygenase-mediated oxidation […

… make up a new class of enzymes that successively oxidizes 5-methylcytosine (5mC) to 5-…
others have shown that Tet protein mediated DNA methylation oxidation regulates gene …

… TET proteins gradually convert 5-methylcytosine into 5-hydroxymethylcytosine, 5-formylcytosine, …
suggest that TET proteins could also be involved in the oxidation of 5-methylcytosine in …

… (C) Tet protein mediated oxidation of 5 mC to oxi-mC derivatives attracts oxi-mC reader
proteins WT1 and CHTOP competing for the same DNA binding sequence. (D) 5mC oxidation to …