… % of patients with advanced cancer. Approximately 45% of all patients with advanced cancer
experience pain of moderate-to-severe intensity (at least 5 on a 0–10 pain rating scale). 8, …

… that neuropathic pain is a representative component of CIBP. However, given the variability
of cancer conditions and the complexity of neuropathic pain, related mechanisms have been …

… Cancer pain remains a significant clinical problem worldwide. Causes of cancer pain are …
systems as an important potential mechanism that may be broadly relevant to many cancer …

… patients with cancer is yet to be achieved. Hence, it is urgent to study the mechanism underlying
… Herein, we focused on the peripheral mechanism associated with the initiation of CIBP, …

… A mechanism-based approach in pain therapy is essential for … The mechanisms which lead
to the development of cancer pain … the pathways and mechanisms of cancer pain and being …

… Metastatic cancer-induced bone pain (CIBP) is a type of chronic pain with unique and … the
mechanisms involved in the occurrence and persistence of cancer-associated bone pain and …

… Several mechanisms cause cancer pain: tumor-producing cytokines and tumor necrosis
factors releasing nociceptive mediators, the proteolytic activity resulting from tissue damage, …

… CIBP is a unique type of pain with nociceptive and neuropathic components but … mechanism
remains unclear. This chapter elaborates on the mechanism of action of bone cancer pain. …

… pain is associated with reduced survival. This article reviews the literature regarding pain:
prevalence, mechanisms… to develop individualized patient pain management pathways. The …

… , pain mechanisms are not distinctly different whether pain is … Cancer-induced bone invasion
sends afferent signals to the … a mechanism common with neuropathic pain). This is a shared …